Raised circulating tenascin-C in rheumatoid arthritis

Table 3 Circulating levels of tenascin-C (TNC) do not correlate with any traditional biomarkers of disease in rheumatoid arthritis (RA)

Cohort	Biomarker	Correlation with TNC at baseline?
Cohort A	CRP	No
	Anti-CCP	No
	ESR	No
	Markers of bone and cartilage metabolism: COMP, CPII, C2C, PIIINP, hyluronan	No
	Clinical score: TJC, SJC	No
	Disease activity: DAS28	No
Cohort B	CRP	No
	Clinical score: TJC, SJC	No
	Disease activity: DAS28	No
Cohort C	CRP	No
	Anti-CCP	No
Cohort D	N/A	N/A

TNC levels at baseline (entry into trial) in four separate cohorts of RA patients were analysed by ELISA. CRP, C-reactive protein; anti-CCP, anti-cyclic citrullinated peptide antibody; COMP, cartilage oligomeric matrix protein; CPII, type II pro collagen; C2C, marker of type II collagen cleavage; ESR, erythrocyte sedimentation rate; PIIINP, procollagen III N-terminal propeptide; TJC, tender joint count; SJC, swollen joint count; DAS28, disease activity score 28; N/A, data not available.

ISSN: 1478-6362