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Table 3 Circulating levels of tenascin-C (TNC) do not correlate with any traditional biomarkers of disease in rheumatoid arthritis (RA)

From: Raised circulating tenascin-C in rheumatoid arthritis

Cohort Biomarker Correlation with TNC at baseline?
Cohort A CRP No
  Anti-CCP No
  ESR No
  Markers of bone and cartilage metabolism: COMP, CPII, C2C, PIIINP, hyluronan No
  Clinical score: TJC, SJC No
  Disease activity: DAS28 No
Cohort B CRP No
  Clinical score: TJC, SJC No
  Disease activity: DAS28 No
Cohort C CRP No
  Anti-CCP No
Cohort D N/A N/A
  1. TNC levels at baseline (entry into trial) in four separate cohorts of RA patients were analysed by ELISA. CRP, C-reactive protein; anti-CCP, anti-cyclic citrullinated peptide antibody; COMP, cartilage oligomeric matrix protein; CPII, type II pro collagen; C2C, marker of type II collagen cleavage; ESR, erythrocyte sedimentation rate; PIIINP, procollagen III N-terminal propeptide; TJC, tender joint count; SJC, swollen joint count; DAS28, disease activity score 28; N/A, data not available.