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Table 3 Overview of the published studies included in the meta-analysis

From: Meta-analysis identified the TNFA -308G > A promoter polymorphism as a risk factor for disease severity in patients with rheumatoid arthritis

Reference

Population

N

Female, %

Age, years

Disease duration,

years

Scoring method

Definition erosive disease

Brinkman [2]

Dutch

144

65

66.8

14.06

ns

Erosions on any radiograph during first 3 years

Pawlik [10]

Polish

91

63

51.7 (range 21-74)#

4.7 ± 2.1

ns

Erosions in chest, hands or feet

Khanna [9]

Americans (Western US) and Mexican

189

76

ns

0.47 (0.3-0.71)*

Sharp

Erosion score ≥ 2 In hand/wrist or feet

Rezaieyazdi [7]

Iranian

34

n.s.

47.3 ± 13.8

4.0 ± 3.7

ns

Erosions in hands

Kazkaz [8]

Syrian

156

80

44.02 ± 14.47

7.28 ± 4.87

Larsen

Destruction score ≥ 2, right wrist

Kazkaz [8]

French

512

75

57.56 ± 14.67

10.05 ± 8.66

Larsen

Destruction score ≥ 2, right wrist

Ates [5]

Turkish

98

80

50.8 ± 12

ns

ns

Erosions in hands or feet

Nemec [6]

Caucasians from Moravian regions of the Czech Republic

130

75

56.21 (20.25-79)*

11.08 (2.08-50.17)*

Steinbrocker

Erosions of stage II-IV in hands

Reneses [4]

Spanish

134

70

50.4 ± 1.3

< 1

Sharp van der Heijde

Erosion at 1 year in hands, wrist or feet

Hussein [3]

Egyptian

172

100

47.4 ± 9.3

10.65 ± 7.9

Sharp

≥ 1 erosions in peripheral joints (hands or feet)

Mosaad [1]

Egyptian

122

80

39.9 ± 10.3

5.9 ± 5.1

Steinbrocker

Erosions in hands

  1. Age and disease duration are depicted as mean ± SD unless stated otherwise. *Median (range); #mean (range); ns, not specified.