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Table 3 Overview of the published studies included in the meta-analysis

From: Meta-analysis identified the TNFA -308G > A promoter polymorphism as a risk factor for disease severity in patients with rheumatoid arthritis

Reference Population N Female, % Age, years Disease duration,
years
Scoring method Definition erosive disease
Brinkman [2] Dutch 144 65 66.8 14.06 ns Erosions on any radiograph during first 3 years
Pawlik [10] Polish 91 63 51.7 (range 21-74)# 4.7 ± 2.1 ns Erosions in chest, hands or feet
Khanna [9] Americans (Western US) and Mexican 189 76 ns 0.47 (0.3-0.71)* Sharp Erosion score ≥ 2 In hand/wrist or feet
Rezaieyazdi [7] Iranian 34 n.s. 47.3 ± 13.8 4.0 ± 3.7 ns Erosions in hands
Kazkaz [8] Syrian 156 80 44.02 ± 14.47 7.28 ± 4.87 Larsen Destruction score ≥ 2, right wrist
Kazkaz [8] French 512 75 57.56 ± 14.67 10.05 ± 8.66 Larsen Destruction score ≥ 2, right wrist
Ates [5] Turkish 98 80 50.8 ± 12 ns ns Erosions in hands or feet
Nemec [6] Caucasians from Moravian regions of the Czech Republic 130 75 56.21 (20.25-79)* 11.08 (2.08-50.17)* Steinbrocker Erosions of stage II-IV in hands
Reneses [4] Spanish 134 70 50.4 ± 1.3 < 1 Sharp van der Heijde Erosion at 1 year in hands, wrist or feet
Hussein [3] Egyptian 172 100 47.4 ± 9.3 10.65 ± 7.9 Sharp ≥ 1 erosions in peripheral joints (hands or feet)
Mosaad [1] Egyptian 122 80 39.9 ± 10.3 5.9 ± 5.1 Steinbrocker Erosions in hands
  1. Age and disease duration are depicted as mean ± SD unless stated otherwise. *Median (range); #mean (range); ns, not specified.