Table 1 Main studies addressing the histopathologic picture of subchondral bone marrow involvement in rheumatoid arthritis
| Â | Number of samples | Disease duration* | Site of surgery | MRI | Main findings |
|---|---|---|---|---|---|
Jimenez-Boj et al. [39] | 12 (12 pts) | 18.9 (± 2.8) | 10 small joints, 1 wrist, 1 large joint | - | Lymphocytic aggregates with predominance of B cells (immunohistochemistry) |
Bugatti et al. [38] | 8 (8 pts) | 12.5 (± 8.8) | 2 small joints, 1 wrist, 5 large joints | - | Lymphocytic aggregates (immunohistochemistry) |
Kuca-Warnawin et al. [23] | 6 (6 pts) | - | 6 large joints | - | Lymphocytic aggregates (immunohistochemistry) |
Jimenez-Boj et al. [35] | 12 (3 pts) | 15.3 (± 8.1) | 12 small joints | Available | Infiltration of hematopoietic cells, lymphocytic aggregates, blood vessels (histology) |
McQueen et al. [36] | 7(4 pts) | 27 (± 11.7) | 7 small joints | Available | Lymphoplasmacytic infiltration, focal necrosis, fibrosis (histology) |
Dalbeth et al. [37] | 28 (11 pts) | 21 (± 9.6) | 23 small joints, 2 wrists, 3 ankles | Available | Infiltration of macrophages, plasma cells, CD8+ T cells, B cells (immunohistochemistry) |
Total | 73 (44 pts) | Â | 54 small joints (hands/feet), 7 wrists/ankles, 12 large joints (knee/hip) | Â | Â |