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Table 1 Main studies addressing the histopathologic picture of subchondral bone marrow involvement in rheumatoid arthritis

From: Inflammatory lesions in the bone marrow of rheumatoid arthritis patients: a morphological perspective

  Number of samples Disease duration* Site of surgery MRI Main findings
Jimenez-Boj et al. [39] 12 (12 pts) 18.9 (± 2.8) 10 small joints, 1 wrist, 1 large joint - Lymphocytic aggregates with predominance of B cells (immunohistochemistry)
Bugatti et al. [38] 8 (8 pts) 12.5 (± 8.8) 2 small joints, 1 wrist, 5 large joints - Lymphocytic aggregates (immunohistochemistry)
Kuca-Warnawin et al. [23] 6 (6 pts) - 6 large joints - Lymphocytic aggregates (immunohistochemistry)
Jimenez-Boj et al. [35] 12 (3 pts) 15.3 (± 8.1) 12 small joints Available Infiltration of hematopoietic cells, lymphocytic aggregates, blood vessels (histology)
McQueen et al. [36] 7(4 pts) 27 (± 11.7) 7 small joints Available Lymphoplasmacytic infiltration, focal necrosis, fibrosis (histology)
Dalbeth et al. [37] 28 (11 pts) 21 (± 9.6) 23 small joints, 2 wrists, 3 ankles Available Infiltration of macrophages, plasma cells, CD8+ T cells, B cells (immunohistochemistry)
Total 73 (44 pts)   54 small joints (hands/feet), 7 wrists/ankles, 12 large joints (knee/hip)   
  1. *Data given as mean (± SD) years. Pts, patients.