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Table 4 Comparison of renal pathological data between lupus nephritis patients with and without renal TMA

From: The spectrum of renal thrombotic microangiopathy in lupus nephritis

  LN with renal TMA LN without renal TMA P-value
Number of biopsies 36 112  
Class II (%) 0 (0) 5 (4.5) 0.336
Class III (%) 3 (8.3) 26 (23.2) 0.05
Class IV (%) 30 (83.3) 65 (58.0) 0.006
Class V (%) 3 (8.3) 16 (14.3) 0.567
AI score (mean ± SD) 10.78 ± 4.16 7.58 ± 4.29 <0.001
Endocapillary hypercellualrity (mean ± SD) 2.78 ± 0.59 2.20 ± 0.99 <0.001
Cellular crescents (mean ± SD) 2.06 ± 1.94 1.38 ± 1.8 0.055
Karyorrhexis/fibrinoid necrosis (mean ± SD) 1.28 ± 1.06 0.95 ± 1.18 0.137
Subendothelial hyaline deposits (mean ± SD) 1.72 ± 1.09 1.10 ± 1.07 0.003
Interstitial inflammation (mean ± SD) 1.63 ± 0.83 1.19 ± 0.72 0.005
Glomerular leukocyte infiltration (median; inter-quartile range) 1
1, 2
1
0, 1
0.006
CI score (mean ± SD) 3.67 ± 1.91 2.80 ± 2.15 0.033
Glomerular sclerosis (mean ± SD) 0.53 ± 0.70 0.48 ± 0.70 0.733
Fibrous crescents (median; inter-quartile range) 0
0, 1
0
0, 0
0.166
Tubular atrophy (mean ± SD) 1.47 ± 0.61 1.06 ± 0.77 0.004
Interstitial fibrosis (mean ± SD) 1.36 ± 0.59 1.02 ± 0.79 0.018