Table 2 Increased risk of upper gastrointestinal bleeding with NSAIDs in two meta-analyses of observational studies
From: Endoscopic ulcers as a surrogate marker of NSAID-induced mucosal damage
Relative risk or odds ratio | ||
|---|---|---|
Drug | Hernández-DÃaz and RodrÃguez[33](1990s, ≥80,000 patients) | Massó González and colleagues[34](2000 to 2008, ≥40,000 patients) |
Ibuprofen ≤,2400 mg | 2.1 (1.6 to 2.7) | 2.7 (2.4 to 3.0) |
Diclofenac ≤100 mg | 3.1 (2.0 to 4.7) | 4.0 (3.5 to 4.4) |
Naproxen ≤1,000 mg | 3.5 (2.8 to 4.3) | 5.2 (4.3 to 6.2) |
Piroxicam ≤20 mg | 5.6 (4.7 to 6.7) | 9.3 (7.5 to 11) |
Current NSAID use | 4.2 (3.9 to 4.6) | 4.6 (4.3 to 4.9) |