Figure 3From: Periodic knee injections of collagen tripeptide delay cartilage degeneration in rabbit experimental osteoarthritisType II collagen expression during osteoarthritis development. Immunohistochemical findings for type II collagen in the medial femoral condylar cartilage from (A) a control knee, (B) a collagen tripeptide (Ctp)-treated knee, (C) a hyaluronan (HA)-treated knee and (D) a Ctp/HA-treated knee 5 weeks after surgery (original magnification ×400). (E) Appearance of type II collagen (×400) staining in the medial femoral condylar cartilage from a normal rabbit knee. (F) Population of type II collagen-positive chondrocytes in medial femoral condylar cartilage of each group 5, 10 and 15 weeks after surgery. Counted area was 6.76 × 104 μm2. Data presented as mean ± standard deviation (*P <0.05).Back to article page