Exercise and obesity in fibromyalgia: beneficial roles of IGF-1 and resistin?

Bjersing, Jan L; Erlandsson, Malin; Bokarewa, Maria I; Mannerkorpi, Kaisa

doi:10.1186/ar4187

Arthritis Research & Therapy

Table 3 Serum free IGF-1, total IGF-1 and IGFB3 in lean, overweight and obese patients

From: Exercise and obesity in fibromyalgia: beneficial roles of IGF-1 and resistin?

	Lean (group 1)			Overweight (group 2)			Obese (group 3)			Comparison of groups
	Baseline Median (range)	∆15 wks Median (range) P-value^a	∆30 wks Median (range) P-value^a	Baseline Median (range)	∆15 wks Median (range) P-value^a	∆30 wks Median (range) P-value^a	Baseline Median (range)	∆15 wks Median (range) P-value^a	∆30 wks Median (range) P-value^a	Groups	At baseline P-value^b	Change after 15 weeks P-value^b	Change after 30 weeks P-value^b
Free IGF-1 ng/ml	4.3 (2.3 to 4.6)	0.8 (-1.1 to 1.4)	0.1 (-5.5 to 0.9)	3.1 (1.7 to 6.3)	-0.4 (-1.5 to 0.5)	-0.7 (-1.6 to 0.6)	5.7 (3.4 to 8.0)	-1.2 (-4.7 to 0.4)	-2.1 (-4.7 to -0.1)	Lean vs overweight	0.697	0.171	0.900
	n = 9	P = 0.515 n = 9	P = 0.753 n = 6	n = 26	P = 0.174 n = 26	P = 0.053 n = 24	n = 13	P = 0.173 n = 13	P = 0.017 n = 10	Lean vs obese	0.164	0.051	0.368
IGFB3 ng/ml	1605.6 (1179.4 to 2397.9)	-260.7 (-578.6 to 36.3)	-568.5 (-899.7 to 123.5)	1492.2 (1079.2 to 1999.4)	106.0 (-370.3 to 942.3)	349.2 (-282.8 to 767.0)	1645.2 (1420.6 to 2002.8)	-19.9 (-622.3 to 544.8)	282.0 (-869.5 to 1558.2)	Lean vs overweight	0.563	0.107	0.095
	n = 8	P = 0.093 n = 8	P = 0.249 n = 6	n = 26	P = 0.397 n = 25	P = 0.128 n = 25	n = 10	P = 0.878 n = 10	P = 0.735 n = 7	Lean vs obese	0.897	0.460	0.628
Total IGF-1 ng/ml	160.0 (123.0 to 187.0)	33.0 (0.0 to 51.0	65.0 (17.8 to 94.3)	113.0 (90.3 to 151.8	10.0 (-13.5 to 19.0)	34.0 (-0.9 to 48.0)	106.5 (95.8 to 157.8)	-1.0 (-21.8 to 4.5)	19.0 (6.0 to 29.0)	Lean vs overweight	0.026	0.065	0.125
	n = 7	P = 0.043 n = 7	P = 0.116	n = 24	P = 0.309 n = 17	P = 0.006	n = 12	P = 0.255 n = 12	P = 0.017	Lean vs obese	0.056	0.010	0.036

Levels of serum free IGF-1, total serum IGF-1 and serum IGFB3 at baseline (0 weeks), change (∆) during training (15 weeks) and change after training (30 weeks). Median values and interquartile range are indicated. ^aWilcoxon signed rank test. ^bMann-Whitney U-test. IGF-1, insulin-like growth factor-1; IGFB3, insulin-like growth factor-binding protein-3.

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