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Table 3 Serum free IGF-1, total IGF-1 and IGFB3 in lean, overweight and obese patients

From: Exercise and obesity in fibromyalgia: beneficial roles of IGF-1 and resistin?

  Lean (group 1) Overweight (group 2) Obese (group 3) Comparison of groups
  Baseline
Median (range)
∆15 wks
Median (range)
P-valuea
∆30 wks
Median (range)
P-valuea
Baseline
Median (range)
∆15 wks
Median (range)
P-valuea
∆30 wks
Median (range)
P-valuea
Baseline
Median (range)
∆15 wks
Median (range)
P-valuea
∆30 wks
Median (range)
P-valuea
Groups At baseline
P-valueb
Change after 15 weeks
P-valueb
Change after 30 weeks
P-valueb
Free
IGF-1
ng/ml
4.3 (2.3 to 4.6) 0.8 (-1.1 to 1.4) 0.1 (-5.5 to 0.9) 3.1 (1.7 to 6.3) -0.4 (-1.5 to 0.5) -0.7 (-1.6 to 0.6) 5.7 (3.4 to 8.0) -1.2 (-4.7 to 0.4) -2.1 (-4.7 to -0.1) Lean vs overweight 0.697 0.171 0.900
  n = 9 P = 0.515
n = 9
P = 0.753
n = 6
n = 26 P = 0.174
n = 26
P = 0.053
n = 24
n = 13 P = 0.173
n = 13
P = 0.017
n = 10
Lean vs obese 0.164 0.051 0.368
IGFB3
ng/ml
1605.6 (1179.4 to 2397.9) -260.7 (-578.6 to 36.3) -568.5 (-899.7 to 123.5) 1492.2 (1079.2 to 1999.4) 106.0 (-370.3 to 942.3) 349.2 (-282.8 to 767.0) 1645.2 (1420.6 to 2002.8) -19.9 (-622.3 to 544.8) 282.0 (-869.5 to 1558.2) Lean vs overweight 0.563 0.107 0.095
  n = 8 P = 0.093
n = 8
P = 0.249
n = 6
n = 26 P = 0.397
n = 25
P = 0.128
n = 25
n = 10 P = 0.878
n = 10
P = 0.735
n = 7
Lean vs obese 0.897 0.460 0.628
Total
IGF-1
ng/ml
160.0 (123.0 to 187.0) 33.0 (0.0 to 51.0 65.0 (17.8 to 94.3) 113.0 (90.3 to 151.8 10.0 (-13.5 to 19.0) 34.0 (-0.9 to 48.0) 106.5 (95.8 to 157.8) -1.0 (-21.8 to 4.5) 19.0 (6.0 to 29.0) Lean vs overweight 0.026 0.065 0.125
  n = 7 P = 0.043
n = 7
P = 0.116 n = 24 P = 0.309
n = 17
P = 0.006 n = 12 P = 0.255
n = 12
P = 0.017 Lean vs obese 0.056 0.010 0.036
  1. Levels of serum free IGF-1, total serum IGF-1 and serum IGFB3 at baseline (0 weeks), change () during training (15 weeks) and change after training (30 weeks). Median values and interquartile range are indicated. aWilcoxon signed rank test. bMann-Whitney U-test. IGF-1, insulin-like growth factor-1; IGFB3, insulin-like growth factor-binding protein-3.