Figure 4

Change in circulating frequencies of Toll-like receptor (TLR)7-expressing precursor myeloid dendritic cells (pre-mDCs) and transcript levels of TLR7-signaling molecules after therapy. The changes in the percentages of circulating TLR7-expressing pre-mDCs (A) and in the transcript levels of TLR7-signaling molecules (B, C, and D), including TLR7, Myeloid differentiation primary-response protein 88 (MyD88), IL-1 receptor-associated kinase (IRAK)4, TNF receptor-associated factor (TRAF)6, IFN regulatory factor (IRF)5, and IFN-α in 12 AOSD patients after therapy. Data are presented as mean ± standard error of the mean. *P <0.005, **P <0.001, versus active phase, determined by the Wilcoxon signed rank test.