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Table 1 Demographic data and clinical characteristics of patients with adult-onset Still's disease (AOSD), patients with systemic lupus erythematosus (SLE) and healthy controls (HC)

From: Involvement of TLR7 MyD88-dependent signaling pathway in the pathogenesis of adult-onset Still's disease

Characteristics AOSD
(n= 28)
SLE
(n= 28)
HC
(n= 12)
Age at study entry, years 37.4 ± 14.8 38.2 ± 8.7 36.4 ± 9.2
Proportion of females 20 (71.4%) 25 (89.3%) 8 (66.7%)
Fever (39°C) 28 (100%) 24 (85.8%) NA
Rash 25 (89.3%) 21 (75.0%) NA
Arthritis 20 (71.4%) 15 (53.6%) NA
Lymphadenopathy 7 (25.0%) 6 (21.4%) NA
Nephritis 0 (0.0%) 9 (32.1%)* NA
Ferritin levels, μg/L 931.0 ± 106.5 NA NA
AOSD activity score 5.93 ± 1.46 NA NA
SLEDAI N A 7.8 ± 2.3 NA
C3 levels, mg/dL NA 84.6 ± 24.7 NA
C4 levels, mg/dL NA 19.5 ± 8.9 NA
Anti-ds DNA, U/mL NA 183.2 ± 200.3 NA
  1. Data are presented as mean ± SD or number (percentage); NA, not applicable. Nephritis is defined by persistent proteinuria (>0.5 g/24 hours), the presence of cellular casts, or pathological examination of renal biopsy specimens showing lupus nephritis. C3 and C4, complement 3 and 4; Anti-ds DNA, anti-double strand DNA antibody; SLEDAI, SLE disease activity index; *P <0.001, versus AOSD patients.