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Table 2 Correlation between transcript levels for TLR7 signaling molecules, and disease activity score and serum cytokine levels in AOSD and SLE patients

From: Involvement of TLR7 MyD88-dependent signaling pathway in the pathogenesis of adult-onset Still's disease

AOSD patients TLR7 MyD88 TRAF6 IRAK4 IRF5 IFN-α
Activity score 0.766*** 0.493* 0.481* 0.488* 0.151 0.489*
MyD88 transcript 0.818*** --     
TRAF6 transcript 0.742*** 0.789*** --    
IRAK4 transcript 0.701** 0.746*** 0.986*** --   
IRF5 transcript 0.241 0.223 0.231 0.218 --  
IFN-α transcript 0.713** 0.738*** 0.988*** 0.986*** 0.254 --
Serum IL-1β level 0.626** 0.424 0.589* 0.531* -0.131 0.556*
Serum IL-6 level 0.589* 0.571* 0.476* 0.434 -0.131 0.455
Serum IL-18 level 0.732** 0.531* 0.451 0.459 -0.033 0.408
Serum TNF-α level 0.117 0.030 0.104 0.059 -0.094 0.036
Serum IFN-α level 0.482* 0.517* 0.558* 0.589* -0.429 0.571*
SLE patients TLR7 MyD88 TRAF6 IRAK4 IRF5 IFN-α
SLEDAI score 0.782** 0.731* 0.486 0.517 0.355 0.698*
MyD88 transcript 0.806** --     
TRAF6 transcript 0.564 0.842*** --    
IRAK4 transcript 0.515 0.685* 0.939*** --   
IRF5 transcript 0.115 -0.236 -0.152 0.127 --  
IFN-α transcript 0.661* 0.855*** 0.976*** 0.952*** -0.139 --
Serum IL-1β level 0.661* 0.334 0.298 0.225 -0.103 0.274
Serum IL-6 level 0.624 0.134 0.036 0.012 -0.024 0.036
Serum IL-18 level 0.770** 0.770** 0.648* 0.588 -0.055 0.721*
Serum TNF-α level 0.261 0.219 0.413 0.547 -0.292 0.474
Serum IFN-α level 0.212 0.456 0.359 0.444 -0.395 0.298
  1. AOSD, adult-onset Still's disease; SLE, systemic lupus erythematosus; SLEDAI, SLE disease activity index; MyD88, Myeloid differentiation primary-response protein 88; TRAF6, TNF receptor associated factor-6; IRAK4, IL-1 receptor-associated kinase-4; IRF5, interferon regulatory factor-5. *P <0.05, **P <0.01, ***P <0.001 (Spearman's rank correlation test).