Involvement of TLR7 MyD88-dependent signaling pathway in the pathogenesis of adult-onset Still's disease

Table 2 Correlation between transcript levels for TLR7 signaling molecules, and disease activity score and serum cytokine levels in AOSD and SLE patients

AOSD patients	TLR7	MyD88	TRAF6	IRAK4	IRF5	IFN-α
Activity score	0.766***	0.493*	0.481*	0.488*	0.151	0.489*
MyD88 transcript	0.818***	--
TRAF6 transcript	0.742***	0.789***	--
IRAK4 transcript	0.701**	0.746***	0.986***	--
IRF5 transcript	0.241	0.223	0.231	0.218	--
IFN-α transcript	0.713**	0.738***	0.988***	0.986***	0.254	--
Serum IL-1β level	0.626**	0.424	0.589*	0.531*	-0.131	0.556*
Serum IL-6 level	0.589*	0.571*	0.476*	0.434	-0.131	0.455
Serum IL-18 level	0.732**	0.531*	0.451	0.459	-0.033	0.408
Serum TNF-α level	0.117	0.030	0.104	0.059	-0.094	0.036
Serum IFN-α level	0.482*	0.517*	0.558*	0.589*	-0.429	0.571*
SLE patients	TLR7	MyD88	TRAF6	IRAK4	IRF5	IFN-α
SLEDAI score	0.782**	0.731*	0.486	0.517	0.355	0.698*
MyD88 transcript	0.806**	--
TRAF6 transcript	0.564	0.842***	--
IRAK4 transcript	0.515	0.685*	0.939***	--
IRF5 transcript	0.115	-0.236	-0.152	0.127	--
IFN-α transcript	0.661*	0.855***	0.976***	0.952***	-0.139	--
Serum IL-1β level	0.661*	0.334	0.298	0.225	-0.103	0.274
Serum IL-6 level	0.624	0.134	0.036	0.012	-0.024	0.036
Serum IL-18 level	0.770**	0.770**	0.648*	0.588	-0.055	0.721*
Serum TNF-α level	0.261	0.219	0.413	0.547	-0.292	0.474
Serum IFN-α level	0.212	0.456	0.359	0.444	-0.395	0.298

AOSD, adult-onset Still's disease; SLE, systemic lupus erythematosus; SLEDAI, SLE disease activity index; MyD88, Myeloid differentiation primary-response protein 88; TRAF6, TNF receptor associated factor-6; IRAK4, IL-1 receptor-associated kinase-4; IRF5, interferon regulatory factor-5. *P <0.05, **P <0.01, ***P <0.001 (Spearman's rank correlation test).

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