Functional neuronal network activity differs with cognitive dysfunction in childhood-onset systemic lupus erythematosus

Table 2 Regions of interest considered per functional magnetic resonance imaging task

Domain: Task	Regions of interest
Working memory: N-back	Frontal, middle + inferior
	Anterior cingulate
	Precuneus
	Parietal, inferior
	Anterior default mode (medial prefrontal cortex) ¹
	Precuneus + posterior cingulate¹
	Angular gyrus¹
	Hippocampus + parahippocampus¹
	Temporal, superior¹
Attention: CTP-IP	Frontal, inferior
	Frontal, middle
	Insula + temporal, superior
	SMA + cingulate, middle
	Parietal, inferior + supramarginal gyrus
	Fusiform gyrus + occipital, inferior
	Frontal mid, inferior + precentral gyrus
	Default, anterior (medial prefrontal cortex) ¹
	Precuneus + posterior cingulate¹
	Angular gyrus¹
	Hippocampus + parahippocampus¹
Visuo-construction: VCA	Frontal, inferior
	Frontal, middle
	Parietal, Inferior + supramarginal gyrus
	Fusiform gyrus + occipital, inferior
	Precuneus, bilateral
	Parietal, superior
	Frontal, superior
	Frontal, superior medial bilateral
	Default, anterior (medial prefrontal cortex)¹
	Precuneus + posterior cingulate¹
	Angular gyrus¹
	Hippocampus + parahippocampus¹

All regions chosen prior to analyses and derived from previously published reports (references [15–18]). ¹Regions hypothesized to deactivate under the task; otherwise, the region is hypothesized to activate. Unless otherwise indicated, right and left hemisphere portions of each region are considered separately in analyses. CPT-IP, continuous performance task-identical pairs; VCA: visuoconstructive ability; SMA, supplementary motor area.

ISSN: 1478-6362