Progression of joint damage in the radiolunate joint. Magnetic resonance imaging (MRI) of the wrist shows thin but present high-signal-intensity cartilage over articular surfaces of the radiolunate joint (large arrow) at baseline (A) associated with grade-1.0 cartilage thinning. Corresponding baseline conventional radiography (XR) (D) shows joint-space narrowing (JSN) at this location (large arrow). Follow-up MRI at 12 weeks (B) and 24 weeks (C) show progressive JSN associated with loss of cartilage over both articular surfaces of this joint, indicative of grade-3.0 cartilage loss. Note development and progression of bone erosions (small arrows) in the radius and lunate on these follow-up scans. Week-24 XR also shows complete radiolunate JSN, the lunate erosion and two of the radius erosions (small arrows). However, the third erosion in the radius is not visible on XR.