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Table 2 Clinical sensitivity and specificity of anti-Th/To antibodies measured by QUANTA Flash Rpp25 vs a commercial line immunoassay for systemic sclerosis (SSc)

From: Rpp25 is a major target of autoantibodies to the Th/To complex as measured by a novel chemiluminescent assay

 

Villalta et al.

Bonroy et al.

Present study

Method

EUROLINE SSc Profile

EUROLINE SSc Profile

QUANTA Flash Rpp25 (CLIA)

Sensitivity1

7/210 (3.3; 1.3, 6.7)

3/145 (2.1; 0.4, 5.9)

2/70 (2.9; 0.3, 9.9)

Specificity2

148/150 (98.7; 95.2, 99.9)

271/277 (97.8; 95.3, 99.2)

365/367 (99.5; 98.0, 99.9)

LR+

2.5

0.96

5.24

LR-

0.98

1.0

0.98

  1. 1Values are presented as number of positives/number of SSc samples tested (percent positive; 95% CI). 2Values are presented as number of negatives/number of non-SSc samples tested (percent negative; 95%CI). LR+, positive likelihood ratio; LR-, negative likelihood ratio; CLIA, chemiluminescent assay.
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Arthritis Research & Therapy

ISSN: 1478-6362

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