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Table 2 Clinical sensitivity and specificity of anti-Th/To antibodies measured by QUANTA Flash Rpp25 vs a commercial line immunoassay for systemic sclerosis (SSc)

From: Rpp25 is a major target of autoantibodies to the Th/To complex as measured by a novel chemiluminescent assay

  Villalta et al. Bonroy et al. Present study
Method EUROLINE SSc Profile EUROLINE SSc Profile QUANTA Flash Rpp25 (CLIA)
Sensitivity1 7/210 (3.3; 1.3, 6.7) 3/145 (2.1; 0.4, 5.9) 2/70 (2.9; 0.3, 9.9)
Specificity2 148/150 (98.7; 95.2, 99.9) 271/277 (97.8; 95.3, 99.2) 365/367 (99.5; 98.0, 99.9)
LR+ 2.5 0.96 5.24
LR- 0.98 1.0 0.98
  1. 1Values are presented as number of positives/number of SSc samples tested (percent positive; 95% CI). 2Values are presented as number of negatives/number of non-SSc samples tested (percent negative; 95%CI). LR+, positive likelihood ratio; LR-, negative likelihood ratio; CLIA, chemiluminescent assay.