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Table 3 Risk estimates for the association of TGFβ1 SNPs with hip OA by being overweight (BMI >25 kg/m2)

From: Gene-environment interaction between body mass index and transforming growth factor beta 1 (TGFβ1) gene in knee and hip osteoarthritis

SNP Genotype Overweight Hip OA Controls Univariate Adjusted† Adjusted‡
    N N OR (95% CI) P-value ORs (95% CI) P-value ORs (95% CI) P-value
rs11466321 11 - 162 273 1.00    1.00    1.00   
  12/22 - 30 41 1.23 (0.74, 2.05) 0.420 1.22 (0.72, 2.06) 0.466 1.18 (0.68, 2.05) 0.552
  11 + 683 548 2.10 (1.68, 2.63) <0.001 2.25 (1.78, 2.84) <0.001 1.97 (1.54, 2.53) <0.001
  12/22 + 125 98 2.17 (1.56, 3.02) <0.001 2.22 (1.58, 3.12) <0.001 1.92 (1.34, 2.74) <0.001
rs8179181 11 - 17 15 1.00    1.00    1.00   
  12/22 - 197 261 0.67 (0.32, 1.37) 0.268 0.57 (0.27, 1.21) 0.143 0.72 (0.33, 1.56) 0.404
  11 + 43 49 0.77 (0.35, 1.73) 0.534 0.75 (0.32, 1.75) 0.505 0.79 (0.33, 1.90) 0.602
  12/22 + 728 617 1.04 (0.52, 2.11) 0.907 0.94 (0.45, 1.97) 0.871 1.03 (0.48, 2.21) 0.944
rs8105161 11 - 9 13 1.00    1.00    1.00   
  12/22 - 182 299 0.88 (0.37, 2.10) 0.772 0.95 (0.39, 2.31) 0.906 0.94 (0.38, 2.33) 0.890
  11 + 19 18 1.52 (0.52, 4.43) 0.438 1.78 (0.59, 5.34) 0.304 1.75 (0.57, 5.41) 0.329
  12/22 + 790 623 1.83 (0.78, 4.32) 0.165 2.09 (0.87, 5.03) 0.098 1.82 (0.74, 4.45) 0.189
rs2278422 11 - 66 113 1.00    1.00    1.00   
  12/22 - 126 197 1.10 (0.75, 1.60) 0.637 1.08 (0.73, 1.60) 0.703 1.07 (0.71, 1.60) 0.751
  11 + 260 182 2.46 (1.72, 3.52) <0.001 2.55 (1.76, 3.70) <0.001 2.26 (1.53, 3.33) <0.001
  12/22 + 542 462 2.01 (1.45, 2.79) <0.001 2.14 (1.52, 3.02) <0.001 1.85 (1.29, 2.65) 0.001
rs2241718 11 - 9 13 1.00    1.00    1.00   
  12/22 - 182 293 0.90 (0.38, 2.14) 0.807 0.95 (0.39, 2.31) 0.905 0.95 (0.38, 2.35) 0.908
  11 + 23 25 1.33 (0.48, 3.69) 0.585 1.60 (0.56, 4.59) 0.377 1.59 (0.54, 4.67) 0.395
  12/22 + 766 607 1.83 (0.78, 4.30) 0.168 2.04 (0.85, 4.90) 0.112 1.78 (0.73, 4.36) 0.205
rs1800468 11 - 174 258 1.00    1.00    1.00   
  12/22 - 17 54 0.47 (0.26, 0.83) 0.010 0.52 (0.28, 0.93) 0.029 0.57 (0.31, 1.05) 0.071
  11 + 661 551 1.78 (1.43, 2.23) <0.001 1.92 (1.52, 2.42) <0.001 1.71 (1.33, 2.18) <0.001
  12/22 + 140 90 2.31 (1.66, 3.20) <0.001 2.47 (1.75, 3.47) <0.001 2.21 (1.55, 3.15) <0.001
rs1800469 11 - 13 27 1.00    1.00    1.00   
  12/22 - 178 281 1.32 (0.66, 2.62) 0.434 1.39 (0.68, 2.84) 0.362 1.37 (0.66, 2.85) 0.396
  11 + 65 59 2.29 (1.08, 4.84) 0.030 2.46 (1.13, 5.35) 0.024 2.09 (0.94, 4.65) 0.072
  12/22 + 727 567 2.67 (1.36, 5.22) 0.004 3.00 (1.50, 6.02) 0.002 2.61 (1.28, 5.35) 0.009
rs1982073 11 - 74 127 1.00    1.00    1.00   
  12/22 - 112 180 1.07 (0.74, 1.55) 0.729 1.11 (0.76, 1.63) 0.594 1.22 (0.82, 1.83) 0.323
  11 + 294 257 1.96 (1.41, 2.74) <0.001 2.22 (1.57, 3.14) <0.001 2.06 (1.44, 2.95) <0.001
  12/22 + 498 374 2.29 (1.67, 3.14) <0.001 2.45 (1.76, 3.40) <0.001 2.27 (1.61, 3.20) <0.001
  1. For Overweight, -indicates not overweight, + indicates overweight; †adjusted for age and gender; ‡adjusted for age, gender, nodal OA, hip injury, occupational risk factors and bone mineral density (Z score); TGFβ1, transforming growth factor β1; SNP, single nucleotide polymorphism; OA, osteoarthritis; OR, odds ratio.