SNP | Genotype | Overweight | Hip OA | Controls | Univariate | Adjusted† | Adjusted‡ | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
N | N | OR | (95% CI) | P-value | ORs | (95% CI) | P-value | ORs | (95% CI) | P-value | |||
rs11466321 | 11 | - | 162 | 273 | 1.00 | 1.00 | 1.00 | ||||||
12/22 | - | 30 | 41 | 1.23 | (0.74, 2.05) | 0.420 | 1.22 | (0.72, 2.06) | 0.466 | 1.18 | (0.68, 2.05) | 0.552 | |
11 | + | 683 | 548 | 2.10 | (1.68, 2.63) | <0.001 | 2.25 | (1.78, 2.84) | <0.001 | 1.97 | (1.54, 2.53) | <0.001 | |
12/22 | + | 125 | 98 | 2.17 | (1.56, 3.02) | <0.001 | 2.22 | (1.58, 3.12) | <0.001 | 1.92 | (1.34, 2.74) | <0.001 | |
rs8179181 | 11 | - | 17 | 15 | 1.00 | 1.00 | 1.00 | ||||||
12/22 | - | 197 | 261 | 0.67 | (0.32, 1.37) | 0.268 | 0.57 | (0.27, 1.21) | 0.143 | 0.72 | (0.33, 1.56) | 0.404 | |
11 | + | 43 | 49 | 0.77 | (0.35, 1.73) | 0.534 | 0.75 | (0.32, 1.75) | 0.505 | 0.79 | (0.33, 1.90) | 0.602 | |
12/22 | + | 728 | 617 | 1.04 | (0.52, 2.11) | 0.907 | 0.94 | (0.45, 1.97) | 0.871 | 1.03 | (0.48, 2.21) | 0.944 | |
rs8105161 | 11 | - | 9 | 13 | 1.00 | 1.00 | 1.00 | ||||||
12/22 | - | 182 | 299 | 0.88 | (0.37, 2.10) | 0.772 | 0.95 | (0.39, 2.31) | 0.906 | 0.94 | (0.38, 2.33) | 0.890 | |
11 | + | 19 | 18 | 1.52 | (0.52, 4.43) | 0.438 | 1.78 | (0.59, 5.34) | 0.304 | 1.75 | (0.57, 5.41) | 0.329 | |
12/22 | + | 790 | 623 | 1.83 | (0.78, 4.32) | 0.165 | 2.09 | (0.87, 5.03) | 0.098 | 1.82 | (0.74, 4.45) | 0.189 | |
rs2278422 | 11 | - | 66 | 113 | 1.00 | 1.00 | 1.00 | ||||||
12/22 | - | 126 | 197 | 1.10 | (0.75, 1.60) | 0.637 | 1.08 | (0.73, 1.60) | 0.703 | 1.07 | (0.71, 1.60) | 0.751 | |
11 | + | 260 | 182 | 2.46 | (1.72, 3.52) | <0.001 | 2.55 | (1.76, 3.70) | <0.001 | 2.26 | (1.53, 3.33) | <0.001 | |
12/22 | + | 542 | 462 | 2.01 | (1.45, 2.79) | <0.001 | 2.14 | (1.52, 3.02) | <0.001 | 1.85 | (1.29, 2.65) | 0.001 | |
rs2241718 | 11 | - | 9 | 13 | 1.00 | 1.00 | 1.00 | ||||||
12/22 | - | 182 | 293 | 0.90 | (0.38, 2.14) | 0.807 | 0.95 | (0.39, 2.31) | 0.905 | 0.95 | (0.38, 2.35) | 0.908 | |
11 | + | 23 | 25 | 1.33 | (0.48, 3.69) | 0.585 | 1.60 | (0.56, 4.59) | 0.377 | 1.59 | (0.54, 4.67) | 0.395 | |
12/22 | + | 766 | 607 | 1.83 | (0.78, 4.30) | 0.168 | 2.04 | (0.85, 4.90) | 0.112 | 1.78 | (0.73, 4.36) | 0.205 | |
rs1800468 | 11 | - | 174 | 258 | 1.00 | 1.00 | 1.00 | ||||||
12/22 | - | 17 | 54 | 0.47 | (0.26, 0.83) | 0.010 | 0.52 | (0.28, 0.93) | 0.029 | 0.57 | (0.31, 1.05) | 0.071 | |
11 | + | 661 | 551 | 1.78 | (1.43, 2.23) | <0.001 | 1.92 | (1.52, 2.42) | <0.001 | 1.71 | (1.33, 2.18) | <0.001 | |
12/22 | + | 140 | 90 | 2.31 | (1.66, 3.20) | <0.001 | 2.47 | (1.75, 3.47) | <0.001 | 2.21 | (1.55, 3.15) | <0.001 | |
rs1800469 | 11 | - | 13 | 27 | 1.00 | 1.00 | 1.00 | ||||||
12/22 | - | 178 | 281 | 1.32 | (0.66, 2.62) | 0.434 | 1.39 | (0.68, 2.84) | 0.362 | 1.37 | (0.66, 2.85) | 0.396 | |
11 | + | 65 | 59 | 2.29 | (1.08, 4.84) | 0.030 | 2.46 | (1.13, 5.35) | 0.024 | 2.09 | (0.94, 4.65) | 0.072 | |
12/22 | + | 727 | 567 | 2.67 | (1.36, 5.22) | 0.004 | 3.00 | (1.50, 6.02) | 0.002 | 2.61 | (1.28, 5.35) | 0.009 | |
rs1982073 | 11 | - | 74 | 127 | 1.00 | 1.00 | 1.00 | ||||||
12/22 | - | 112 | 180 | 1.07 | (0.74, 1.55) | 0.729 | 1.11 | (0.76, 1.63) | 0.594 | 1.22 | (0.82, 1.83) | 0.323 | |
11 | + | 294 | 257 | 1.96 | (1.41, 2.74) | <0.001 | 2.22 | (1.57, 3.14) | <0.001 | 2.06 | (1.44, 2.95) | <0.001 | |
12/22 | + | 498 | 374 | 2.29 | (1.67, 3.14) | <0.001 | 2.45 | (1.76, 3.40) | <0.001 | 2.27 | (1.61, 3.20) | <0.001 |