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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Open label study of escalating doses of oral treprostinil diethanolamine in patients with systemic sclerosis and digital ischemia: pharmacokinetics and correlation with digital perfusion

Figure 3

Median drug concentration, perfusion, and skin temperature over time. Graphs depict the median log-transformed treprostinil plasma concentration time profile (Panel A) in pg/mL for subjects reaching a 2 mg BID dose (N = 8) and 4 mg BID dose (N = 6) and corresponding changes in median skin perfusion in PU (Panel B) and skin temperature in ÂșC (Panel C) over time. Bars represent the interquartile (25th to 75th percentile) range. BID, twice daily; PU, perfusion units.

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