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Table 5 Contribution of mutations of RGYW/WRCY sequences to all mutations (%) in VL gene rearrangements of B cells from the peripheral blood and from the parotid gland of a patient with Sjögren's syndrome (SS), and of peripheral blood B cells from normal healthy subjects (NHS)

From: Analysis of immunoglobulin light chain rearrangements in the salivary gland and blood of a patient with Sjögren's syndrome

  SS peripheral blood (%) SS parotid gland (%) NHS peripheral blood (%)
   
   Nonproductive 18.2* 23.5 38
   Productive 45.0* 48.1 51.3
   
   Nonproductive 50.0 20.0 50.6
   Productive 43.2 50.6 63.3
  1. Significant difference of the contribution of mutations of RGYW/WRCY sequences to all mutations comparing nonproductive and productive Vλ gene rearrangements: *P = 0.018 (chi-square test), peripheral blood B cells from the patient with SS; P = 0.049, B cells from the parotid gland; and P < 0.0001, B cells from the peripheral blood of NHS [27].