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Table 3 Improved aerobic capacity and endurance performance after 12 weeks of endurance exercise in myositis patients.

From: Improved exercise performance and increased aerobic capacity after endurance training of patients with stable polymyositis and dermatomyositis

  Before
Mean ± SD
After
Mean ± SD
Paired t-test
Exercise group (EG)
Endurance cycling test ( n = 9)
Time to exhaustion (minutes) 15.4 + 5.1 33.7 + 13.3 P <0.01
Lactate (mM) 10.3 ± 2.5 6.5 ± 1.8 P <0.01
Percentage maximum heart rate 88 ± 8 88 ± 5 n.s.
Borg rating (6 to 20):    
   Peripheral exertion 19 ± 1 17 ± 2 n.s.
   Central exertion 19 ± 1 17 ± 2 n.s.
VO 2 max test ( n = 7)
VO2 max (l min-1) 1.63 ± 0.30 1.91 ± 0.30 P <0.01
Power at VO2 max (W) 119 ± 25 138 ± 26 P <0.001
Mitochondrial enzyme activities ( n = 3)
Citrate synthase
(μmol (g dw-1) min-1)
42.9 ± 2.0 76.8 ± 1.4 P <0.001
β-hydroxyacyl-CoA dehydrogenase
(β-HAD; μmol (g dw-1) min-1)
33.5 ± 6.5 50.1 ± 1.9 P <0.05
Control group (CG)
Endurance cycling test ( n = 6)
Time to exhaustion (minutes) 13.7 ± 4.5 14.5 ± 4.8 n.s.
Lactate (mM) 9.9 ± 3.1 11.3 ± 3.5 n.s.
Percentage maximum heart rate 97 ± 2 95 ± 3 n.s.
Borg rating (6 to 20):    
   Peripheral exertion 18 ± 2 18 ± 3 n.s.
   Central exertion 17 ± 2 17 ± 2 n.s.
VO 2 max test ( n = 5)
VO2 max (l min-1) 1.46 ± 0.30 1.32 ± 0.21 P <0.05
Power at VO2 max (W) 110 ± 16 102 ± 18 n.s.
Mitochondrial enzyme activities ( n = 5)
Citrate synthase
(μmol (g dw-1) min-1)
52.8 ± 7.3 50.3 ± 13.0 n.s.
β-hydroxyacyl-CoA dehydrogenase
(β-HAD; μmol (g dw-1) min-1)
43.8 ± 10.1 36.7 ± 10.5 n.s.
  1. n.s., Non-significant; VO2 max, maximal oxygen uptake; endurance cycling test, time cycling to exhaustion performed with a constant power, which in each individual was set to requiring 65% of baseline VO2 max; Borg rating, rating of exertion at end of VO2 max test and at the end of the endurance cycling test; Lactate, concentration of lactate measured in muscle vastus lateralis with microdialysis directly after the endurance cycling test.