Figure 2
Top 25 differentially expressed genes in cartilage ageing. The heat map illustrates the 25 most highly upregulated and downregulated genes in cartilage. The counts represent raw counts for each donor. Significance was set at P < 0.05 and ± 1.4 log2 fold-change in gene expression based on mapped reads following normalisation and statistical testing in edgeR [24]. Orange, less counts; white, greater number of counts.