Transcriptomic signatures in cartilage ageing

Table 3 SNORDs and SNORAs identified as being differentially expressed in ageing cartilage.

Name	Family	Action	Target	Log₂ fold-change	Higher
SNORD113	C/D BOX	Site-specific 2'-O-methylation	Not predicted to target rRNA or snRNA.	29.6	Young
SNORA53	H/ACA box	H/ACA family of pseudouridylation guide snoRNAs	Not identified	29.9	Young
SNORA79	H/ACA box	H/ACA family of pseudouridylation guide snoRNAs	Not identified	5.3	Young
SNORA48	H/ACA box	H/ACA family of pseudouridylation guide snoRNAs	28SrRNA	4.1	Young
SNORD12/SNORD16	C/D BOX	Site-specific 2'-O-methylation	28srRNA, 18SrRNA	3.2	Young
RNase P	RNase MRP related	Site-specific endonuclease, ribosome biogenesis, pre-rRNA processings	Numerous	1.7	Young
Rnase MRP	Rnase MRP	Site-specific endonuclease	Numerous	2	Young
U1 splicesomal RNA	Splicesome	Complex of snRNA and protein subunits that removes introns from a transcribed pre-mRNA		2.3	Young
U2 splicesomal RNA	Splicesome	Complex of snRNA and protein subunits that removes introns from a transcribed pre-mRNA		2.3	Young
SNORA40	H/ACA box class	H/ACA family of pseudouridylation guide snoRNAs	28SrRNA	-1.5	Old
SNORA5	H/ACA box class	H/ACA family of pseudouridylation guide snoRNAs	Not identified	-1.9	Old
SNORA30/SNORA37	H/ACA box class	H/ACA family of pseudouridylation guide snoRNAs	28SrRNA	-2.7	Old
Small nucleolar RNA U89	H/ACA box class	H/ACA family of pseudouridylation guide snoRNAs	Not identified	-1.4	Old
U4 splicesomal RNA	Splicesome	Complex of snRNA and protein subunits that removes introns from a transcribed pre-mRNA		-2.2	Old
U6 splicesomal RNA	Splicesome	Complex of snRNA and protein subunits that removes introns from a transcribed pre-mRNA		-2.1	Old

The class of action and target of these RNAs are shown with higher differential gene expression (DGE) in young or old cartilage. rRNA, ribosomal RNA; snoRNA, small nucleolar RNA.

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