Is serum HMGB1 a biomarker in ANCA-associated vasculitis?

Table 3 HMGB1 levels as a biomarker of relapse risk in antineutrophil cytoplasmic antibodies-associated vasculitis patients

HMGB1 levels	Hazard rate	95% confidence interval	P value
At baseline	0.812	0.529 to 1.248	0.327
At early remission^a	0.963	0.641 to 1.446	0.854
At ongoing remission	1.344	0.746 to 2.420	0.325
Prior to relapse 1	0.967	0.776 to 1.205	0.762
Delta between early remission and prior to relapse 1	0.959	0.751 to 1.226	0.739
Delta between ongoing remission and prior to relapse 1	0.919	0.728 to 1.161	0.478

Cox hazard proportional model to evaluate the role of HMGB1 levels as a biomarker of relapse risk in antineutrophil cytoplasmic antibodies-associated vasculitis patients. HMGB1, high-mobility group box 1. ^aEarly remission indicates when remission was achieved.

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