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Table 4 Association between joint space narrowing (JSN) progression and bone marrow lesion (BML) volume change

From: Evaluation of bone marrow lesion volume as a knee osteoarthritis biomarker - longitudinal relationships with pain and structural changes: data from the Osteoarthritis Initiative

   JSN progression   
Rank for change in BML volume Median
(min, max) cm 3
No Yes Odds ratio*
(95% CI)
Overall
P value
Medial or lateral JSN progression (n = 350)     
BML regression (n = 87) -0.97 (-12.59, -0.46) 66 (76%) 21 (24%) 1.86 (0.96 to 3.60)  
No to minimal BML change (n = 176)
(middle two quartiles collapsed)
-0.05 (-0.46, 0.24) 150 (85%) 26 (15%) Reference 0.11
BML progression (n = 87) 0.73 (0.25, 10.02) 66 (76%) 21 (24%) 1.79 (0.92 to 3.46)  
Medial JSN progression (n = 301)      
Medial TF BML regression (n = 75) -0.97 (-9.48, -0.46) 53 (74%) 19 (26%) 3.07 (1.44 to 6.57)  
No to minimal medial TF BML change (n = 151)
(middle two quartiles collapsed)
-0.08 (-0.46, 0.23) 130 (89%) 16 (11%) Reference 0.01
Medial TF BML progression (n = 75) 0.65 (0.23, 4.76) 58 (81%) 14 (19%) 1.62 (0.73 to 3.61)  
  1. All changes are based on change between the 24- and 48-month Osteoarthritis Initiative visits. *Odds ratios are adjusted for sex, baseline age (<65 years, ≥65 years), and baseline body mass index (<30 kg/m2, ≥30 kg/m2). 95% CI, 95% confidence interval; TF, tibiofemoral.