Figure 3
From: Anti-TNF-α antibody allows healing of joint damage in polyarthritic transgenic mice
Histology shows significant healing of arthritic joints in young Tg197 mice after treatment with anti-TNF-α mAb. Tissue sections of the ankle joints were obtained from young Tg197 mice with established arthritis at baseline (a,b) and after 6 weeks of treatment with saline (c,d) or anti-TNF-α (e,f). Sections were stained with hematoxylin and eosin (a, c, e) or toluidine blue (b, d, f). The arrows in panels (a) and (b) indicate areas of cell infiltration (1), erosions (2) and loss of proteoglycan from cartilage (3). Original magnification, 20×. mAb, monoclonal antibody; TNF, tumor necrosis factor.