Histology scores for synovitis, bone erosion, and cartilage degradation in aged mice. Joint tissues were harvested at baseline (n = 5), after 6 weeks of saline treatment (n = 10), or after 6 weeks (n = 5) or 16 weeks (n = 5) of anti-TNF-α treatment. All paws were subjected to blinded histologic analysis. *P < 0.05, versus baseline; +P < 0.05, versus saline-treated controls. mAb, monoclonal antibody; TNF, tumor necrosis factor.