Therapeutic administration of sclerostin antibody to arthritic mice does not repair focal bone erosion in periarticular bone in the ankle joint. (A, B, C) Bar plots represent mean (and standard deviation of) smoothness parameter (BSsmooth/BS), ratio between bone surface and bone volume (BS/BV), representing surface density, and ankle joint bone volume (BV), respectively. CTR, age-matched healthy controls (n = 4). The one-way ANOVA test with Tukey's post hoc comparison was used for statistical evaluation of all parameters shown in the bar plots. *P < 0.05 for the difference versus control (CTR); #P < 0.05 for the difference versus collagen-induced arthritis (CIA) + PBS.