Independent associations of total and high molecular weight adiponectin with cardiometabolic risk and surrogate markers of enhanced early atherogenesis in black and white patients with rheumatoid arthritis: a cross-sectional study

Table 4 Independent relations of high molecular weight adiponectin concentrations* with cardiometabolic risk and surrogate markers of enhanced early atherogenesis in African black and white patients with rheumatoid arthritis

			Patients
	Interaction		All (n = 210)		Black (n = 119)		White (n = 91)
Characteristic	Partial R	P	Partial R	P	Partial R	P	Partial R	P
Metabolic risk factor
Systolic blood pressure	0.122	0.09	0.217	0.002	0.304	0.001	0.123	0.1
Diastolic blood pressure	0.022	0.7	0.155	0.03	0.257	0.01	0.143	0.2
Mean blood pressure	0.107	0.1	0.216	0.002	0.298	0.002	0.143	0.2
Total cholesterol	-0.149	0.04	-0.002	1.0	-0.095	0.3	0.074	0.5
HDL cholesterol*	0.214	0.003	0.214	0.003	0.292	0.003	0.180	0.1
Total-HDL cholesterol ratio	-0.190	0.009	-0.196	0.006	-0.302	0.002	-0.112	0.3
LDL cholesterol	-0.119	0.1	-0.036	0.6	-0.121	0.2	0.018	0.8
Non-HDL cholesterol	-0.190	0.009	-0.094	0.1	-0.221	0.03	-0.002	1.0
Triglycerides*	-0.212	0.009	-0.137	0.05	-0.269	0.006	-0.003	0.9
Triglycerides-HDL cholesterol ratio*	-0.211	0.003	-0.202	0.004	-0.329	0.0008	0.094	0.4
Glucose*	-0.215	0.003	-0.155	0.03	-0.246	0.01	-0.143	0.2
Number of metabolic risk factors	-0.193	0.007	-0.155	0.03	-0.210	0.03	-0.148	0.2
Early atherogenesis
Selectin	-0.044	0.5	-0.013	0.9	-0.051	0.6	-0.019	0.8
VCAM-1*	-0.079	0.2	0.128	0.08	-0.007	0.9	0.240	0.03
ICAM-1*	-0.129	0.08	0.103	0.1	-0.007	0.9	0.286	0.009
MCP-1*	-0.054	0.4	0.021	0.8	-0.011	0.9	0.153	0.1
Endothelial activation score	-0.123	0.07	0.098	0.1	-0.058	0.5	0.252	0.02

Relationships were determined in demographic characteristic, log glomerular filtration, cardiovascular drug use and waist circumference adjusted models. Significant associations are shown in bold. *Log transformed. HDL, High density lipoprotein; ICAM, Intercellular adhesion molecule; LDL, low density lipoprotein; MCP, Monocyte chemoattractant protein; VCAM, Vascular cell adhesion molecule.

ISSN: 1478-6362