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Table 2 Time course of composite measures and remission rate stratified by DAS28 (ESR) at discontinuation of ADA

From: Discontinuation of adalimumab after attaining disease activity score 28-erythrocyte sedimentation rate remission in patients with rheumatoid arthritis (HONOR study): an observational study

 

DAS28 (ESR) ≤2.16 at discontinuation (n = 32)

2.16 <DAS28 (ESR) <2.6 at discontinuation (n = 18)

Week 0

Week 24

Week 0

Week 24

mean ± SD

median (IQR)

mean ± SD

median (IQR)

mean ± SD

median (IQR)

mean ± SD

median (IQR)

TJC28

0.06 ± 0.25

0 (0, 0)

1.28 ± 3.27

0 (0, 1)

0.22 ± 0.55

0 (0, 0)

1.39 ± 2.09

0 (0, 2.5)

SJC28

0.03 ± 1.77

0 (0, 0)

0.41 ± 0.98

0 (0, 0)

0.0 ± 0.0

0 (0, 0)

1.17 ± 2.33

0 (0, 1)

PGA (mm)

5.41 ± 6.38

2 (0, 10)

9.75 ± 12.15

4.5 (0.3, 15.8)

8.72 ± 15.08

4 (1.5, 7.5)

16.17 ± 23.63

5 (0.75, 27)

EGA (mm)

2.25 ± 3.62

1 (0, 2.8)

7.22 ± 12.13

1.5 (0, 9.5)

2.50 ± 3.07

2 (0, 3.25)

10.72 ± 16.57

5.5 (0, 10.5)

ESR (mm/hr)

9.78 ± 4.11

9 (6.3, 12)

15.78 ± 10.07

14 (10, 18.8)

24.39 ± 9.05

24.5 (17.5, 32)

39.33 ± 20.55

37 (21.5, 53.75)

CRP (mg/dl)

0.11 ± 0.17

0.04 (0.01, 0.11)

0.35 ± 0.65

0.1 (0.05, 0.30)

0.11 ± 0.22

0.04 (0.03, 0.08)

0.22 ± 0.23

0.15 (0.04, 0.2)

CDAI

0.86 ± 1.00

0.4 (0.03, 1.5)

3.38 ± 5.95

1.0 (0.1, 3.0)

1.34 ± 1.83

0.6 (0.275, 1.7)

5.24 ± 7.32

2.2 (0.075, 9.2)

SDAI

0.97 ± 1.01

0.45 (0.2, 1.8)

3.74 ± 6.23

1.1 (0.3, 4.2)

1.44 ± 1.81

0.8 (0.3, 1.775)

5.45 ± 7.37

2.55 (0.275, 0.2)]

DAS28 (ESR)

1.65 ± 0.34

1.70 (1.45, 2.00)

2.30 ± 1.11

2.00 (1.80, 2.43)

2.41 ± 0.15

2.46 (2.27, 2.54)

3.24 ± 1.14

2.78 (2.54, 3.64)

HAQ

0.14 ± 0.23

0 (0, 0.3)

0.18 ± 0.39

0 (0, 0.1)

0.38 ± 0.38

0.31 (0, 0.66)

0.40 ± 0.44

0.25 (0, 0.78)

mTSS

27.86 ± 61.96

8 (2.5, 23)

  

64.41 ± 111.33

9 (0.5, 88)

  
 

n/N

percent

n/N

percent

n/N

percent

n/N

percent

DAS28 (ESR) <2.6

32/32

100%

25/32

78.1%

18/18

100%

4/18

22.2%

DAS28 (ESR) <3.2

32/32

100%

27/32

84.4%

18/18

100%

11/18

61.1%

CDAI ≤2.8

31/32

96.9%

24/32

75.0%

15/18

83.3%

11/18

61.1%

SDAI ≤3.3

31/32

96.9%

23/32

71.9%

15/18

83.3%

11/18

61.1%

Boolean definition

25/32

78.1%

21/32

65.6%

15/18

83.3%

10/18

55.6%

  1. CDAI, clinical disease activity index; CRP, C-reactive protein; DAS28 (ESR), disease activity score by using 28 joints based on erythrocyte sedimentation rate; EGA, evaluator’s global assessment; ESR, erythrocyte sedimentation rate; HAQ, Health Assessment Questionnaire; LOCF, last observation carried forward; mTSS, modified total Sharp score, Boolean definition: ACR/EULAR 2010 definition criteria of clinical remission (TJC ≤1, SJC ≤1, PGA ≤1 cm, CRP ≤1 mg/dl); PGA, patient’s global assessment; SDAI, simplified disease activity index; SJC, swollen joint count; TJC, tender joint count.