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Table 2 Autoantibody and disease features of patients with the five major autoantibodies against citrullinated protein profiles a

From: ACPA fine-specificity profiles in early rheumatoid arthritis patients do not correlate with clinical features at baseline or with disease progression

Group n Anti-CCP2+b(%) RF+ (%) Mean ACPA level (U/ml) Mean number of citrullinated antigens recognized (range)c,d (Ex-) smokers (%)e SE+f(%)d VAS mediang
C 15 100 93 4630 6 (1 to 16) 38 93 34
D 83 88 87 1317 3 (1 to 13) 59 80 35
E 30 87 87 861 2 (0 to 5) 66 70 34
F 198 31 45 137 0 (0 to 4) 49 53 40
H 17 0 29 14 0 (0 to 1) 60 29 50
  1. aACPA: anticitrullinated protein antibody; CCP2: cyclic citrullinated peptide 2; RF: rheumatoid factor; SE: shared epitope; VAS: Visual Analogue Scale score. bMeasured using the anti-CCP2 test (CCPlus Immunoscan assay). cReactivity is based upon cutoff values determined with reactivity of healthy individuals with surface plasmon resonance imaging. dP-value < 0.01. eP-value = 0.278. fAt least one SE allele. gP-value = 0.958. Group differences were tested using the Kruskal-Wallis test or Pearson’s χ2 test.