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Table 3 Basic data and 2 × 2 comparisons to detect the strongest human leukocyte antigen association of the risk factors a

From: HLA and non-HLA genes in Behçet’s disease: a multicentric study in the Spanish population

A*02

B*51

BD patients

Controls

+

+

72

29

+

76

112

+

45

11

73

161

A*24

B*51

  

+

+

26

6

+

36

30

+

91

34

119

237

B*57

B*51

  

+

+

8

0

+

24

11

+

111

40

131

262

Factor 1-B*51

A*02

 

 A*24

 

 B*57

 
 

P c

OR

P c

OR

P c

OR

Test 1

>0.05

0.62

>0.05

1.54

>0.05

6.17

Test 2

>0.05

1.49

0.008

2.38

<0.0006

4.25

Test 3

<0.0006

5.40

<0.0006

8.10

0.0012

33.9

Test 4

<0.0006

0.17

>0.05

0.45

>0.05

0.77

  1. aBD, Behçet’s disease; HLA, human leukocyte antigen; odds ratio; Pc, corrected value of P. Test 1: ++ vs. –+ was performed to determine whether the HLA proposed factor was associated in B*51 positives. Test 2: +- vs. –– was designed to determine whether the HLA proposed factor was associated in B*51 negatives. Test 3: ++ vs. –– was conducted to determine the combined association between the HLA proposed factor and HLA-B*51. Test 4: +- vs. –+ was done to determine whether the associations between the HLA proposed factor and HLA-B*51 were different. Pc was calculated from the different 2 × 2 tables using Fisher’s exact test and corrected by multiplying by 6 (see [23]). Each comparison included B*51 and other HLA risk factors associated with the disease or suggestive of an association with the disease.