A*02
|
B*51
|
BD patients
|
Controls
|
+ | + | 72 | 29 |
+ | – | 76 | 112 |
– | + | 45 | 11 |
– | – | 73 | 161 |
A*24
|
B*51
| | |
+ | + | 26 | 6 |
+ | – | 36 | 30 |
– | + | 91 | 34 |
– | – | 119 | 237 |
B*57
|
B*51
| | |
+ | + | 8 | 0 |
+ | – | 24 | 11 |
– | + | 111 | 40 |
– | – | 131 | 262 |
Factor 1-B*51
|
A*02
| |
A*24
| |
B*57
| |
|
P
c
|
OR
|
P
c
|
OR
|
P
c
|
OR
|
Test 1 | >0.05 | 0.62 | >0.05 | 1.54 | >0.05 | 6.17 |
Test 2 | >0.05 | 1.49 | 0.008 | 2.38 | <0.0006 | 4.25 |
Test 3 | <0.0006 | 5.40 | <0.0006 | 8.10 | 0.0012 | 33.9 |
Test 4 | <0.0006 | 0.17 | >0.05 | 0.45 | >0.05 | 0.77 |
- aBD, Behçet’s disease; HLA, human leukocyte antigen; odds ratio; Pc, corrected value of P. Test 1: ++ vs. –+ was performed to determine whether the HLA proposed factor was associated in B*51 positives. Test 2: +- vs. –– was designed to determine whether the HLA proposed factor was associated in B*51 negatives. Test 3: ++ vs. –– was conducted to determine the combined association between the HLA proposed factor and HLA-B*51. Test 4: +- vs. –+ was done to determine whether the associations between the HLA proposed factor and HLA-B*51 were different. Pc was calculated from the different 2 × 2 tables using Fisher’s exact test and corrected by multiplying by 6 (see [23]). Each comparison included B*51 and other HLA risk factors associated with the disease or suggestive of an association with the disease.