Figure 4

Disease severity in sialoadhesin (Sn)^+/+and Sn^−/−NZBWF1 mice. (A) Disease onset and progression was determined by measurement of proteinuria in each of the indicated genotypes; n = 7, 10 and 10 mice per group for Sn^+/+, Sn^+/− and Sn^−/− respectively. (B) Serum immunoassays of IgM and IgG anti-dsDNA at 18, 22 and 26 weeks of age. (C) Light microscopy-based scoring of disease severity in glomerular, tubulointerstitial and perivascular compartments in 28-week old mice; n = 6 mice per group.