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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Cholesterol accumulation caused by low density lipoprotein receptor deficiency or a cholesterol-rich diet results in ectopic bone formation during experimental osteoarthritis

Figure 4

Enhanced serum cholesterol levels increase ectopic bone formation in ligaments. The size of cartilage and bone formations was measured using digital image analysis. The incidence of ectopic bone formation was increased after a cholesterol-rich diet, LDL receptor deficiency and the combination of these two (A). The photographs depict representative examples of ectopic bone formation at the medial collateral ligament (B). When cross-sectional surface areas were measured, a cholesterol-rich diet or LDL receptor deficiency showed increased total enthesophyte size in ligaments (C). ns = not significant compared to other groups; ‡P<0.05 compared to WT mice with normal diet. LDL, low density lipoprotein; WT, wild type.

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Arthritis Research & Therapy

ISSN: 1478-6362

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