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Table 4 BMD and microarchitectural parameters in AS patients with a vertebral fracture compared with age-matched AS patients without a vertebral fracture

From: Bone microarchitecture in ankylosing spondylitis and the association with bone mineral density, fractures, and syndesmophytes

  

Patients without a vertebral fracture (mean ± SD)

Patients with a vertebral fracture (mean ± SD)

Difference%

P value

  

n = 16

n = 8

  
 

Age (years)

55.9 ± 12.4

55.6 ± 12.8

-0.01

0.955

QCT lumbar spine

Trab vBMD (mg/cm3)

117.17 ± 34.35

92.09 ± 40.94

-21.4

0.128

 

Cort vBMD (mg/cm3)

366.11 ± 81.62

285.45 ± 52.77

-22.0

0.019

DXA BMD

AP lumbar (g/cm2)

1.10 ± 0.11

0.98 ± 0.13

-10.9

0.018

 

Lat lumbar (g/cm2)

0.80 ± 0.11

0.68 ± 0.10

-15.0

0.021

 

Lumb vBMD (g/cm3)

0.20 ± 0.03

0.17 ± 0.03

-15.0

0.048

 

Femoral neck (g/cm2)

0.80 ± 0.11

0.66 ± 0.12

-17.5

0.009

 

Total hip (g/cm2)

1.00 ± 0.10

0.83 ± 0.13

-17.0

0.002

 

Radius 1/3 (g/cm2)

0.79 ± 0.05

0.78 ± 0.08

-1.3

0.672

 

Total radius (g/cm2)

0.66 ± 0.05

0.62 ± 0.07

-6.1

0.188

HRpQCT

DTrab (mg/cm3)

195.42 ± 40.31

147.20 ± 27.10

-24.7

0.010

Radius

 

BV/TV (%)

16.3 ± 3.4

12.3 ± 2.3

-25.0

0.010

 

Tbth (μm)

83.1 ± 19.9

65.1 ± 7.9

-12.5

0.034

 

TbN (per mm)

1.98 ± 0.26

1.88 ± 0.23

-5.1

0.388

 

TbSp (μm)

430.0 ± 66.1

473.1 ± 64.7

+9.3

0.169

 

DCort (mg/cm3)

862.81 ± 38.45

810.70 ± 68.01

-6.0

0.032

 

CortTh (μm)

901 ± 163

637 ± 181

-28.9

0.003

 

CortCSA (mm2)

76.81 ± 11.63

55.11 ± 14.17

-28.3

0.001

 

CtPo (%)

2.65 ± 0.97

2.39 ± 1.07

-9.8

0.548

 

CtPoDiam (μm)

172 ± 18

165 ± 15

-4.1

0.548

HRpQCT

DTrab (mg/cm3)

189.52 ± 25.76

155.59 ± 39.46

-17.9

0.052

Tibia

 

BV/TV (%)

15.8 ± 2.1

13.0 ± 3.3

-18.8

0.050

 

Tbth (μm)

78.6 ± 9.4

68.4 ± 9.4

-12.5

0.020

 

TbN (per mm)

2.01 ± 0.18

1.88 ± 0.26

-6.4

0.149

 

TbSp (μm)

421.9 ± 44.8

474.6 ± 89.1

+14.3

0.150

 

DCort (mg/cm3)

848.24 ± 51.18

810.19 ± 83.08

-4.5

0.263

 

CortTh (μm)

1,303 ± 297

946 ± 352

-26.9

0.016

 

CortCSA (mm2)

151.94 ± 26.71

115.50 ± 38.91

-24.0

0.013

 

Ct Po (%)

7.27 ± 2.94

7.54 ± 3.27

+3.7

0.881

 

CtPoDiam (μm)

189 ± 16

194 ± 17

+2.6

0.417

  1. Difference (%), mean of fractured – mean of nonfractured/mean of nonfractured; BMD, bone mineral density; BV/TV, trabecular bone volume fraction; Cort, cortical; DCort, vBMD of cortical peripheral bone; DTrab, vBMD of trabecular peripheral bone; DXA, dual-energy x-ray absorptiometry; CortCSA, cortical cross-sectional area peripheral bone; CortTh,cortical thickness peripheral bone, CtPo = cortical porosity; CtPoDiam, mean cortical pore diameter; HRpQCT, high-resolution peripheral quantitative computed tomography; TbN, trabecular number peripheral bone; TbSp, trabecular separation peripheral bone; Tbth, trabecular thickness peripheral bone; Trab, trabecular; vBMD, volumetric BMD; QCT, quantitative computed tomography.