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Table 4 BMD and microarchitectural parameters in AS patients with a vertebral fracture compared with age-matched AS patients without a vertebral fracture

From: Bone microarchitecture in ankylosing spondylitis and the association with bone mineral density, fractures, and syndesmophytes

   Patients without a vertebral fracture (mean ± SD) Patients with a vertebral fracture (mean ± SD) Difference% P value
   n = 16 n = 8   
  Age (years) 55.9 ± 12.4 55.6 ± 12.8 -0.01 0.955
QCT lumbar spine Trab vBMD (mg/cm3) 117.17 ± 34.35 92.09 ± 40.94 -21.4 0.128
  Cort vBMD (mg/cm3) 366.11 ± 81.62 285.45 ± 52.77 -22.0 0.019
DXA BMD AP lumbar (g/cm2) 1.10 ± 0.11 0.98 ± 0.13 -10.9 0.018
  Lat lumbar (g/cm2) 0.80 ± 0.11 0.68 ± 0.10 -15.0 0.021
  Lumb vBMD (g/cm3) 0.20 ± 0.03 0.17 ± 0.03 -15.0 0.048
  Femoral neck (g/cm2) 0.80 ± 0.11 0.66 ± 0.12 -17.5 0.009
  Total hip (g/cm2) 1.00 ± 0.10 0.83 ± 0.13 -17.0 0.002
  Radius 1/3 (g/cm2) 0.79 ± 0.05 0.78 ± 0.08 -1.3 0.672
  Total radius (g/cm2) 0.66 ± 0.05 0.62 ± 0.07 -6.1 0.188
HRpQCT DTrab (mg/cm3) 195.42 ± 40.31 147.20 ± 27.10 -24.7 0.010
Radius
  BV/TV (%) 16.3 ± 3.4 12.3 ± 2.3 -25.0 0.010
  Tbth (μm) 83.1 ± 19.9 65.1 ± 7.9 -12.5 0.034
  TbN (per mm) 1.98 ± 0.26 1.88 ± 0.23 -5.1 0.388
  TbSp (μm) 430.0 ± 66.1 473.1 ± 64.7 +9.3 0.169
  DCort (mg/cm3) 862.81 ± 38.45 810.70 ± 68.01 -6.0 0.032
  CortTh (μm) 901 ± 163 637 ± 181 -28.9 0.003
  CortCSA (mm2) 76.81 ± 11.63 55.11 ± 14.17 -28.3 0.001
  CtPo (%) 2.65 ± 0.97 2.39 ± 1.07 -9.8 0.548
  CtPoDiam (μm) 172 ± 18 165 ± 15 -4.1 0.548
HRpQCT DTrab (mg/cm3) 189.52 ± 25.76 155.59 ± 39.46 -17.9 0.052
Tibia
  BV/TV (%) 15.8 ± 2.1 13.0 ± 3.3 -18.8 0.050
  Tbth (μm) 78.6 ± 9.4 68.4 ± 9.4 -12.5 0.020
  TbN (per mm) 2.01 ± 0.18 1.88 ± 0.26 -6.4 0.149
  TbSp (μm) 421.9 ± 44.8 474.6 ± 89.1 +14.3 0.150
  DCort (mg/cm3) 848.24 ± 51.18 810.19 ± 83.08 -4.5 0.263
  CortTh (μm) 1,303 ± 297 946 ± 352 -26.9 0.016
  CortCSA (mm2) 151.94 ± 26.71 115.50 ± 38.91 -24.0 0.013
  Ct Po (%) 7.27 ± 2.94 7.54 ± 3.27 +3.7 0.881
  CtPoDiam (μm) 189 ± 16 194 ± 17 +2.6 0.417
  1. Difference (%), mean of fractured – mean of nonfractured/mean of nonfractured; BMD, bone mineral density; BV/TV, trabecular bone volume fraction; Cort, cortical; DCort, vBMD of cortical peripheral bone; DTrab, vBMD of trabecular peripheral bone; DXA, dual-energy x-ray absorptiometry; CortCSA, cortical cross-sectional area peripheral bone; CortTh,cortical thickness peripheral bone, CtPo = cortical porosity; CtPoDiam, mean cortical pore diameter; HRpQCT, high-resolution peripheral quantitative computed tomography; TbN, trabecular number peripheral bone; TbSp, trabecular separation peripheral bone; Tbth, trabecular thickness peripheral bone; Trab, trabecular; vBMD, volumetric BMD; QCT, quantitative computed tomography.