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Table 4 Comparison of cytokine profile in SF according to ACPA status (number = 51)

From: Differences in synovial fluid cytokine levels but not in synovial tissue cell infiltrate between anti-citrullinated peptide/protein antibody-positive and –negative rheumatoid arthritis patients

SF cytokines Total ACPA positive ACPA negative P value
Number = 51 Number = 40 Number = 11
GM-CSF (pg/ml) 0 (0 to 0) 0 (0 to 0) 0 (0 to 0) 0.461
IFNγ (pg/ml) 0 (0 to 0) 0 (0 to 0) 0 (0 to 0) 0.828
IL-1β (pg/ml) 0 (0 to 7.9) 2.61 (0 to 12.2) 0 (0 to 0) 0.011
IL-2 (pg/ml) 0 (0 to 159.3) 38.9 (0 to 164) 0 (0 to 0) 0.076
IL-4 (pg/ml) 0 (0 to 0) 0 (0 to 0) 0 (0 to 0) 0.280
IL-5 (pg/ml) 0 (0 to 0) 0 (0 to 0) 0 (0 to 0) 0.714
IL-6 (pg/ml) 1,252.6 (4.3 to 47.4) 1,260.8 (774.9 to 1,725.1) 1,170.6 (628.8 to 1,568.4) 0.697
IL-10 (pg/ml) 16.2 (4.3 to 47.4) 26.7 (6.9 to 57.1) 0 (0 to 13.4) 0.001
IL-12p70 (pg/ml) 0 (0 to 0) 0 (0 to 0) 0 (0 to 0) 0.682
IL-13 (pg/ml) 0 (0 to 0) 0 (0 to 0) 0 (0 to 0) 0.688
IL-17 (pg/ml) 0 (0 to 26.2) 0 (0 to 33.2) 0 (0 to 0) 0.160
IL-17 F (pg/ml) 142.7 (0 to 532.6) 269.9 (23.1 to 534.8) 9.2 (0 to 71.2) 0.021
IL-21 (pg/ml) 783 (0 to 1,162.4) 820.8 (0 to 1,158.3) 0 (0 to 1,381.4) 0.493
IL-22 (pg/ml) 0 (0 to 0) 0 (0 to 91.8) 0 (0 to 0) 0.207
IL-23 (pg/ml) 259 (0 to 863.1) 311.7 (0 to 1,028.4) 169.4 (0 to 472.3) 0.372
CCL20 (pg/ml) 445.5 (59.0 to 3,521.1) 1,437.9 (179.3 to 3,928.0) 39.2 (5.6 to 161.9) <0.0001
TGF-β1 (pg/ml) 768 (0 to 1,927.7) 924.4 (0 to 1,918.3) 0 (0 to 2,035.3) 0.277
TNFα (pg/ml) 0 (0 to 16.3) 0 (0 to 16.2) 0 (0 to 17.6) 0.636
TNFβ (pg/ml) 0 (0 to 13.1) 0 (0 to 13) 0 (0 to 15.2) 0.759
  1. Data are expressed as median (IQR). CCL20: CC chemokine ligand 20, GM-CSF: Granulyte macrophage-colony stimulating factor, TGF: Transforming growth factor, TNF: Tumor necrosis factor.