Table 4 Comparison of cytokine profile in SF according to ACPA status (number = 51)
SF cytokines | Total | ACPA positive | ACPA negative | P value |
|---|---|---|---|---|
Number = 51 | Number = 40 | Number = 11 | ||
GM-CSF (pg/ml) | 0 (0 to 0) | 0 (0 to 0) | 0 (0 to 0) | 0.461 |
IFNγ (pg/ml) | 0 (0 to 0) | 0 (0 to 0) | 0 (0 to 0) | 0.828 |
IL-1β (pg/ml) | 0 (0 to 7.9) | 2.61 (0 to 12.2) | 0 (0 to 0) | 0.011 |
IL-2 (pg/ml) | 0 (0 to 159.3) | 38.9 (0 to 164) | 0 (0 to 0) | 0.076 |
IL-4 (pg/ml) | 0 (0 to 0) | 0 (0 to 0) | 0 (0 to 0) | 0.280 |
IL-5 (pg/ml) | 0 (0 to 0) | 0 (0 to 0) | 0 (0 to 0) | 0.714 |
IL-6 (pg/ml) | 1,252.6 (4.3 to 47.4) | 1,260.8 (774.9 to 1,725.1) | 1,170.6 (628.8 to 1,568.4) | 0.697 |
IL-10 (pg/ml) | 16.2 (4.3 to 47.4) | 26.7 (6.9 to 57.1) | 0 (0 to 13.4) | 0.001 |
IL-12p70 (pg/ml) | 0 (0 to 0) | 0 (0 to 0) | 0 (0 to 0) | 0.682 |
IL-13 (pg/ml) | 0 (0 to 0) | 0 (0 to 0) | 0 (0 to 0) | 0.688 |
IL-17 (pg/ml) | 0 (0 to 26.2) | 0 (0 to 33.2) | 0 (0 to 0) | 0.160 |
IL-17 F (pg/ml) | 142.7 (0 to 532.6) | 269.9 (23.1 to 534.8) | 9.2 (0 to 71.2) | 0.021 |
IL-21 (pg/ml) | 783 (0 to 1,162.4) | 820.8 (0 to 1,158.3) | 0 (0 to 1,381.4) | 0.493 |
IL-22 (pg/ml) | 0 (0 to 0) | 0 (0 to 91.8) | 0 (0 to 0) | 0.207 |
IL-23 (pg/ml) | 259 (0 to 863.1) | 311.7 (0 to 1,028.4) | 169.4 (0 to 472.3) | 0.372 |
CCL20 (pg/ml) | 445.5 (59.0 to 3,521.1) | 1,437.9 (179.3 to 3,928.0) | 39.2 (5.6 to 161.9) | <0.0001 |
TGF-β1 (pg/ml) | 768 (0 to 1,927.7) | 924.4 (0 to 1,918.3) | 0 (0 to 2,035.3) | 0.277 |
TNFα (pg/ml) | 0 (0 to 16.3) | 0 (0 to 16.2) | 0 (0 to 17.6) | 0.636 |
TNFβ (pg/ml) | 0 (0 to 13.1) | 0 (0 to 13) | 0 (0 to 15.2) | 0.759 |