Figure 5
Effect of PEA-LUT combination therapy on cytokines, chemokine expression, and neutrophil infiltration. A substantial increase in the expression of MIP-1α (A), MIP-2 (B), IL-1β (C), IL-6 (D), TNF-α (E), and MPO activity (F) was found in CIA-control mice 35 days after CII immunization. CIA-PEA-treated mice demonstrated a significant reduction in the expression of MIP-1α (A), MIP-2 (B), IL-1β (C), IL-6 (D), TNF-α (E), and MPO activity (F). CIA-LUT-treated mice did not significantly reduce the expression of MIP-1α (A), MIP-2 (B), IL-1β (C), IL-6 (D), TNF-α (E), and MPO activity (F). The combination therapy with PEA-LUT significantly reduced the expression of MIP-1α (A), MIP-2 (B), IL-1β (C), IL-6 (D), TNF-α (E), and MPO activity (F). Values are shown as mean ± SEM of 20 animals for each group. *P < 0.01 versus Sham-control. °P < 0.01 versus CIA-control. # P < 0.01 versus CIA-PEA. § P < 0.01 versus CIA-LUT.