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Table 3 Multivariable logistic-regression model results for complications associated with hip or knee TJA a

From: Rheumatoid arthritis patients are not at increased risk for 30-day cardiovascular events, infections, or mortality after total joint arthroplasty

Variable

Any post-op cardiovascular event

Any post-op infection

Deep wound surgical-site infection

Any complications

Post-op stay (β in days)

Return to operating room within 30 days

Mortalityb

RA versus OA c

0.66 (0.35, 1.24)

1.14 (0.80, 1.62)

0.35 (0.12, 1.08)

1.07 (0.80, 1.43)

-0.18 (-0.73, 0.38)

1.41 (1.05, 1.90)

1.22 (1.00, 1.49)

Age c

1.03 (1.02, 1.04)

1.03 (1.02, 1.03)

0.99 (0.98, 1.01)

1.02 (1.02, 1.03)

0.10 (0.08, 0.12)

1.00 (0.99, 1.01)

1.06 (1.05, 1.06)

Male sex c

1.04 (0.66, 1.64)

0.68 (0.53, 0.87)

0.77 (0.46, 1.29)

0.8 (0.67, 0.95)

-1.06 (-1.51, -0.61)

1.05 (0.78, 1.42)

d

Hip versus knee TJA c

0.88 (0.73, 1.05)

1.10 (0.96, 1.26)

0.96 (0.68, 1.35)

1.10 (0.99, 1.23)

0.62 (0.33, 0.90)

1.38 (1.17, 1.63)

1.24 (1.16, 1.33)

Operation Time (in hours)

1.10 (1.00, 1.22)

1.11 (1.01, 1.23)

1.22 (1.04, 1.43)

1.16 (1.08, 1.24)

1.10 (0.75, 1.45)

1.23 (1.13, 1.33)

1.30 (1.19, 1.41)

General anesthesia

 

1.17 (1.00, 1.39)

1.43 (0.98, 2.10)

1.17 (1.04, 1.32)

   

Calendar year (1998–2006)

 

1.03 (1.00, 1.07)

  

-0.28 (-0.37, -0.18)

  

Caucasian race

    

-0.98 (-1.68, -0.28)

  

Alcohol consumption

   

1.19 (1.02, 1.39)

  

1.23 (1.09, 1.38)

Current smoker

0.78 (0.62, 1.00)

 

1.72 (1.30, 2.26)

   

1.57 (1.45, 1.71)

Poor functional health

 

1.48 (1.20, 1.81)

1.66 (1.07, 2.58)

 

1.62 (0.79, 2.46)

1.42 (1.13, 1.78)

 

Short of breath, dyspnea ≥2

1.53 (1.22, 1.93)

  

1.27 (1.10, 1.47)

 

1.36 (1.10, 1.66)

1.20 (1.09, 1.32)

COPD history

1.27 (1.01, 1.60)

1.81 (1.52, 2.16)

 

1.47 (1.27, 1.70)

0.54 (0.22, 0.87)

 

1.45 (1.32, 1.60)

Bleeding disorder

2.34 (1.63, 3.37)

1.83 (1.28, 2.62)

     

Pre-op open wound/infection

3.02 (1.28, 7.13)

2.46 (1.32, 4.60)

 

2.73 (1.62, 4.61)

 

2.86 (1.53, 5.35)

1.91 (1.20, 3.04)

TIA history

2.03 (1.46, 2.81)

  

1.41 (1.11, 1.79)

   

Stroke history w/impairment

    

1.23 (0.49, 1.96)

  

Stroke history w/o impairment

     

1.49 (1.00, 2.21)

1.21 (1.02, 1.44)

CHF <30 days pre-op

   

1.53 (1.02, 2.29)

2.54 (0.61, 4.47)

 

1.55 (1.22, 1.96)

Impaired sensorium

      

2.30 (1.61, 3.28)

Diabetes: oral treatment

 

1.18 (1.02, 1.37)

1.59 (1.14, 2.21)

1.2 (1.05, 1.37)

   

Diabetes: insulin treatment

 

1.36 (1.09, 1.69)

2.48 (1.65, 3.73)

1.41 (1.18, 1.70)

   

Diabetes: oral or insulin

    

0.40 (0.16, 0.64)

  

Chemotherapy <30 days preop

      

1.72 (1.19, 2.49)

Low-dose aspirin

 

0.76 (0.64, 0.90)

0.47 (0.33, 0.67)

0.77 (0.68, 0.88)

 

0.71 (0.62, 0.82)

0.65 (0.60, 0.70)

White blood cells >11,000/μl

      

1.35 (1.16, 1.56)

Creatinine >1.2 mg/dl

1.20 (1.00, 1.44)

      

Hematocrit ≤38%

 

1.21 (1.04, 1.42)

 

1.25 (1.12, 1.40)

  

1.47 (1.36, 1.58)

Serum sodium >145 m M

 

1.64 (1.07, 2.52)

     

GCS (30 days)

 

0.75 (0.58, 0.96)

 

0.82 (0.69, 0.97)

   

GCS (6 months)

  

1.86 (1.33, 2.60)

    

GCS (1 year)

    

0.45 (0.18, 0.72)

  

GCS (VASQIP)

      

1.52 (1.26, 1.82)

Constant

    

557.9

  
  1. aExcept where noted, odds ratios (95% CI).
  2. bCox proportional hazards regression, hazard ratios (95% CI).
  3. cVariable was forced into all models.
  4. dNot significant and removed for not meeting proportional hazard requirement.
  5. CHF, congestive heart failure; COPD, chronic obstructive pulmonary disease; GCS, glucocorticosteroid; OA, osteoarthritis; RA, rheumatoid arthritis; TIA, transient ischemic attack. TJA, total joint arthroplasty.
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Arthritis Research & Therapy

ISSN: 1478-6362

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