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Table 4 The prevalence of AECA and autoantibodies directed to specific antigens of ANCA

From: Epitope analysis of anti-myeloperoxidase antibodies in propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis

AECA and ANCA directed to specific antigens other than MPO Number and percentage with ANCA specificity
Patients with PTU-induced vasculitis Patients with PTU-induced MPO-ANCA but without clinical vasculitis P value
(n = 17) (n = 11)
AECA 15 (88.2%) 0 (0) <0.001
PR3 5 (29.4%) 1 (9.1%) 0.380
HLE 12 (70.6%) 3 (27.3%) 0.011
Lactoferrin 14 (82.4%) 5 (45.5%) 0.010
Cathepsin G 11 (64.7%) 0 (0) <0.001
BPI 0 (0) 1 (9.1%) 0.209
Azurocidin 12 (70.6%) 1 (9.1%) <0.001
Number of ANCA target antigens recognized 3 (2–4) 0 (0–2%) <0.001
  1. PR3, Proteinase 3; HLE, human leukocyte elastase; BPI, bactericidal/permeability-increasing protein.