Epitope analysis of anti-myeloperoxidase antibodies in propylthiouracil-induced antineutrophil cytoplasmic antibody-associated vasculitis

Table 4 The prevalence of AECA and autoantibodies directed to specific antigens of ANCA

AECA and ANCA directed to specific antigens other than MPO	Number and percentage with ANCA specificity
	Patients with PTU-induced vasculitis	Patients with PTU-induced MPO-ANCA but without clinical vasculitis	P value
	(n = 17)	(n = 11)	P value
AECA	15 (88.2%)	0 (0)	<0.001
PR3	5 (29.4%)	1 (9.1%)	0.380
HLE	12 (70.6%)	3 (27.3%)	0.011
Lactoferrin	14 (82.4%)	5 (45.5%)	0.010
Cathepsin G	11 (64.7%)	0 (0)	<0.001
BPI	0 (0)	1 (9.1%)	0.209
Azurocidin	12 (70.6%)	1 (9.1%)	<0.001
Number of ANCA target antigens recognized	3 (2–4)	0 (0–2%)	<0.001

PR3, Proteinase 3; HLE, human leukocyte elastase; BPI, bactericidal/permeability-increasing protein.