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Table 5 Most frequently prescribed drugs a

From: Remarkable prevalence of coeliac disease in patients with irritable bowel syndrome plus fibromyalgia in comparison with those with isolated irritable bowel syndrome: a case-finding study

Prescribed drugs IBS IBS/FMS P value IBS/FMS cases classified by Marsh stage P value
(N = 125) (N = 104) (BIS vs. FMS) Marsh stage 0 (N = 39) Marsh stage 1 (N = 58) Marsh stage 3 (N = 7) (Marsh stages 1 and 3 vs. Marsh stage 0)
Analgesicsb 22 (18) 85 (82) <0.001 34 (87) 45 (78) 6 (86) 0.468
Omeprazole 102 (82) 82 (79) 0.360 29 (74) 47 (81) 6 (86) 0.659
Antidepressantsc 30 (24) 70 (67) <0.001 25 (64) 40 (69) 5 (71) 0.857
Pregabalin 4 (3) 60 (58) <0.001 19 (49) 36 (62) 5 (71) 0.319
Benzodiazepines/hypnotics 55 (44) 59 (57) 0.037 20 (51) 35 (60) 4 (57) 0.677
Antispasmodics/antidiarrhoealsd 58 (46) 52 (50) 0.341 17 (38) 33 (57) 2 (29) 0.220
Laxatives 14 (11) 42 (40) <0.001 10 (26) 27 (47) 5 (71) 0.027
Opiate patches 17 (16) NA 1 (2) 12 (21) 4 (57) <0.001
Number of drugs prescribed per patient per day 1.8 (1.1) 4.6 (2.2) <0.001 3.9 (1.9) 4.9 (2.2) 6.6 (1.5) 0.003
  1. aIBS, inflammatory bowel syndrome; IBS/FMS, inflammatory bowel syndrome/fibromyalgia syndrome; NA = not applicable. bAnalgesics were usually used on an irregular basis (on demand) and were generally nonsteroidal anti-inflammatory drugs, acetaminophen, tramadol, metamizole and codeine. cAntidepressants prescribed were tricyclic antidepressants, selective serotonin reuptake inhibitors or other antidepressants. dAntispasmodics prescribed were mebeverine and/or octylonium bromide, and antidiarrhoeal medications prescribed were loperamide and diphenoxylate/atropine. Data are expressed as total value and percentage of the total value or mean and standard deviation.