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Table 6 Haematological and biochemical laboratory findings a

From: Remarkable prevalence of coeliac disease in patients with irritable bowel syndrome plus fibromyalgia in comparison with those with isolated irritable bowel syndrome: a case-finding study

Laboratory panels

IBS

IBS/FMS

P value

IBS/FMS cases classified by Marsh stage

P value

(N = 125)

(N = 104)

(IBS vs. FMS)

Marsh stage 0 (N = 39)

Marsh stage 1 (N = 58)

Marsh stage 3 (N = 7)

(Marsh stages 1 and 3 vs. Marsh stage 0)

Haemoglobin, g/dl

13 ( 1)

13 (1)

1.000

13 (1)

14 (1)

13 (1)

0.271

WBC count, n × 103

7.6 (1)

7.0 (2)

0.002

7.6 (1)

6.7 (2)

5.8 (2)

0.002

Platelet count, n × 103

272 (37)

257 (54)

0.021

274 (37)

248 (60)

232 (57)

0.010

Prothrombin activity (%)

98 (5)

98 (9)

0.777

98.2 (8)

98 (10)

98 (4)

0.741

aPTT, seconds

34 (2)

35 (2)

0.024

35 (2)

33 (2)

33 (1)

0.019

Fibrinogen, mg/dl

261 (111)

349 (152)

<0.001

259 (113)

385 (128)

552 (218)

<0.001

Glucose, mg/dl

108 (27)

101 (20)

0.018

109 (27)

96 (13)

99 (9)

0.020

Urea, mg/dl

44 (23)

40 (14)

0.022

43 (21)

38 (7)

38 (8)

0.017

CK, IU/L

59 (7)

60 (9)

0.985

58 (7)

61 (10)

62 (12)

0.276

CRP, mg/L

0.6 (0.6)

0.5 (0.6)

0.211

0.6 (0.7)

0.5 (0.7)

0.3 (0.2)

0.466

IgG, g/L

9.7 (0.5)

9.9 (1.0)

0.098

9.6 (0.5)

10.2 (1.2)

9.6 (1.0)

0.107

IgA, g/L

2.4 (0.5)

2.6 (0.6)

0.126

2.4 (0.6)

2.7 (0.6)

2.4 (0.5)

0.008

IgM, g/L

1.8 (0.4)

1.9 (0.5 )

0.126

1.9 (0.3)

1.9 (0.6)

1.6 (0.5)

0.722

Iron, μg/ml

68 (19)

80 (29)

0.001

66 (20)

89 (32)

91 (21)

<0.001

Ferritin, ng/ml

56 (23)

88 (164)

0.821

48 (28)

114 (214)

90 (70)

0.064

TSI, μg/dl

20 (11)

24 (9)

0.001

20 (11)

25 (8)

25 (6)

0.001

Cholesterol, g/dl

176 (24)

174 (39)

0.293

192 (18)

166 (42)

144 (52)

0.001

AST, IU/L

20 (9)

23 (9)

<0.001

21 (5)

25 (11)

30 (20)

0.269

ALT, IU/L

21 (6)

25 (13)

0.803

21 (7)

27 (17)

19 (10)

0.765

GGT, IU/L

23 (20)

28 (23)

0.074

24 (20)

31 (22)

23 (33)

0.060

ALP, IU/L

70 (23)

76 (26)

0.012

74 (30)

78 (23)

77 (22)

0.066

Bilirubin, mg/dl

0.7 (0.2)

0.8 (0.2)

0.639

0.7 (0.1)

0.7 (0.2)

0.9 (0.24)

0.591

TSH, μU/ml

1.8 (0.6)

3.1 (5.9)

0.209

1.9 (0.7)

4.1 (7.8)

1.2 (0.8)

0.157

Folate, ng/dl

10 (4)

9 (3)

0.019

10 (3)

8 (3)

10 (5)

0.019

Vitamin B12, pg/ml

451 (168)

521 (206)

0.002

450 (170)

555 (213)

636 (238)

0.001

RF, IU/ml

13 (1)

13 (2)

0.858

13 (1)

13 (2)

14 (2)

0.775

ANAs (+)

4 (3)

29 (28)

<0.001

3 (8)

23 (40)

3 (43)

0.002

Titres

       

1:160

4 (3)

23 (22)

<0.001

4 (10)

18 (31)

1 (14)

0.004

1:320

–

3 (3)

NA

–

2 (3)

1 (14)

NA

1:640

–

3 (3)

NA

–

2 (3)

1 (14)

NA

Staining pattern

       

Speckled

4 (3)

25 (24)

<0.001

4 (10)

21 (34)

–

NA

Homogeneous

–

2 (2)

NA

–

1 (2)

1 (14)

NA

Nucleolar

–

2 (2)

NA

–

–

2 (29)

NA

Anti-TPO (+)

–

12 (11)

NA

–

10 (17)

2 (29)

0.011

Serum levels, IU/ml

–

31 (108)

NA

–

51 (140)

40 (72)

NA

AMAs (+)

–

5 (4)

NA

–

4 (7)

1 (0)

NA

Titres

       

1:160

–

1 (1)

NA

–

1 (2)

–

NA

1:320

–

2 (2)

NA

–

1 (3)

1 (14)

NA

1:640

–

2 (2)

NA

–

2 (3)

–

NA

  1. aALP, alkaline phosphatase; ALT, alanine aminotransferase; AMA, antimitochondrial antibody; ANA, antinuclear antibody; Anti-TPO, antithyroid peroxidase antibody; aPTT, activated partial thromboplastin time; AST, aspartate aminotransferase; CK, creatine kinase; CRP, C-reactive protein; GGT, γ-glutamyl transpeptidase; Ig, immunoglobulin; NA, not applicable; RF, rheumatoid factor; TSH, thyroid-stimulating hormone; TSI, Transferrin Saturation Index; WBC, white blood cell. Values are expressed as mean and standard deviation or total value and percentage.
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Arthritis Research & Therapy

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