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Table 1 Multivariate analysis of tocilizumab-induced increases in haemoglobin at week 12

From: Effect of tocilizumab on haematological markers implicates interleukin-6 signalling in the anaemia of rheumatoid arthritis

Statistical model Coefficient SE P
Basic linear model in the tocilizumab arm a
Intercept 2.20 1.93 0.26
Baseline haemoglobin, g/dl -0.19 0.14 0.20
Change log(CRP) baseline, week 2 -0.048 0.15 0.75
log(Hepcidin) change from baseline to week 2, fmol/μl -0.044 0.11 0.69
Haptoglobin change from baseline to week 2, fmol/μl -0.0052 0.0028 0.076
Male 0.042 0.45 0.93
Refined multivariate model b
Intercept 2.20 1.68 0.20
Baseline haemoglobin, g/dl -0.18 0.12 0.15
log(Haptoglobin) change from baseline to week 2, fmol/μl -0.0060 0.0021 0.0079
  1. aMultiple r2 = 0.30, P = 0.047; bMultiple r2 = 0.29, P < 0.0033. CRP, C-reactive protein; SE, standard error.