Figure 5

The occurrence of FXIIa-antithrombin (AT) is clearly linked to platelet activation. Plasma levels of thrombospondin 1 (TSP-1) (A), platelet expression of P-selectin (CD62P) (B), platelet count (C), platelet-leukocyte complexes (D), platelet intracellular levels of the type I IFN-regulated proteins (IFITM1) and protein kinase IFN-inducible double-stranded RNA dependent activator (PRKRA) (E and F), all parameters reflecting platelet activation, were assessed in systemic lupus erythematosus (SLE) patients (n = 69). All parameters were shown to statistically correlate with FXIIa-AT tested with Spearman’s rank-order correlation coefficients (r _s ).