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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Serum level of adiponectin is a surrogate independent biomarker of radiographic disease progression in early rheumatoid arthritis: results from the ESPOIR cohort

Figure 2

Association of baseline serum adipokine levels and radiographic evidence of disease progression defined as an increase of ≥1 in total Sharp/van der Heijde score (SHS) between inclusion and 1 year. Multivariate models: model 1 (“base”): sex + age. Model 2 (“metabolic”): model 1 + BMI + HOMA-IR index. Model 3 (“metabolic + RA”): model 2 + CRP level + DAS28-ESR value + HAQ score + RF status + anti-CCP antibody status + presence of radiographic changes at inclusion. Model 4 (“metabolic + RA + steroid”): model 3 + steroid prescription at inclusion. DAS28, Disease Activity Score in 28 joints; CRP, C-reactive protein level; ESR: erythrocyte sedimentation rate; RF, rheumatoid factor; HAQ, Health Assessment Questionnaire; BMI, body mass index; HOMA-IR, Homeostatic Model Assessment of Insulin Resistance.

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