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Table 1 Baseline and week-12 characteristics in patients

From: Deficient spontaneous in vitro apoptosis and increased tmTNF reverse signaling-induced apoptosis of monocytes predict suboptimal therapeutic response of rheumatoid arthritis to TNF inhibition

 

All patients

Baseline

  

Week 12

 
  

Responder (week 12)

Nonresponder (week 12)

All patients

Responder

Nonresponder

Number

20

10

10

20

10

10

TJC of 28 joints

8.25 (±7.2)

9.20 (±8.7)

7.30 (±5.8)

3.16 (±3.3)

2.20 (±3,2)

4.22 (±3.3)

SJC of 28 joints

5.45 (±3.7)

5.90 (±3.1)

5.00 (±4.3)

1.79 (±2.7)

0.70 (±1.9)

3.00 (±3.1)

VAS general disease activity

47.8 (±20.4)

52.6 (±19.3)

42.9 (±21.4)

27.6 (±18.6)

21.6 (±16.9)

34.2 (±19.1)

ESR, mm/h

23.7 (±13.6)

19.1 (±10.5)

28.3 (±15.3)

17.8 (±14.2)

11.1 (±7.3)

25.1 (±16.7)

C reactive protein, mg/dl

7.22 (±6.5)

6.65 (±4.9)

7.79 (±8.0)

5.40 (±8.9)

2.71 (±3.1)

8.3 (±12.3)

DAS28

4.76 (±1.2)

4.82 (±1.2)

4.7 (±1.2)

3.33 (±1.4)

2.50 (±1.1)

4.17 (±1.2)

Age, years

53.65 (±9.4)

53.5 (±10.7)

53.8 (±8.5)

-

-

-

Sex, female, %

70

60

80

-

-

-

Disease duration, years

4.35

4.3

4.4

-

-

-

Rheumatoid factor, +/-, %

65/35

70/30

60/40

-

-

-

Anti CCP, +/-, %

80/20

80/20

80/20

-

-

 
  1. TJC, tender joint count; SJC, swollen joint count; VAS, visual analog scale; ESR, erythrocyte sedimentation rate; DAS28, disease activity score in 28 joints; CCP, cyclic citrullinated peptide.