Figure 3

Pharmacological evaluation. Effect of morphine (6 mg/Kg, s.c., A, B), lidocaine (5 mg, i.a., C, D) or diclofenac (30 mg/Kg, p.o., E, F) on movement- and loading-induced nociception assessed by the Knee-Bend ( A , C , E ) and the CatWalk ( B , D , F ) tests, at one, two, four and six weeks after injection of 500 U of collagenase. A: Morphine effectively reversed the Knee-Bend scores at all time-points of disease progression. B: Morphine was effective at one, two and six weeks of disease progression. C: Lidocaine effectively reversed the Knee-Bend scores at all time-points of disease progression. D: Lidocaine was effective at two, four and six weeks of disease progression. E: Diclofenac effectively reversed the Knee-Bend scores one week after injection. F: Diclofenac was effective one week after injection. Mean ± SEM. Repeated measures ANOVA followed by Dunnett’s post-hoc test; *P <0.05, **P <0.01, ***P <0.001.