From: Review of pharmacological therapies in fibromyalgia syndrome
Drug | Contraindications | Warnings and precautions | Last update |
---|---|---|---|
Pregabalin | 1. Known hypersensitivity to pregabalin or any of its components | 1. Suicidal behavior and ideation | June 2011 |
2. Usage in pregnancy | |||
3. Hypersensitivity reactions | |||
4. Angioedema | |||
5. Peripheral edema | |||
6. Dizziness and sleepiness with impairment of the ability to drive or operate machinery | |||
7. Gynecomastia and breast enlargement | |||
Duloxetine | 1. Concomitant use of monoaminooxidase inhibitors | 1. Suicidality | Jan. 2010 |
2. Uncontrolled narrow-angle glaucoma | 2. Hepatotoxicity | ||
3. Substantial alcohol use or evidence of chronic liver damage | 3. Orthostatic hypotension and syncope | ||
4. Severe renal impairment | 4. Serotonin- or neuroleptic syndrome-like reactions | ||
 | 5. Abnormal bleeding | ||
6. Discontinuation syndrome | |||
7. Activation of mania | |||
8. Blood pressure control | |||
9. Hyponatremia | |||
10. Glucose control in diabetes | |||
11. Slow gastric emptying | |||
12. Urinary hesitation and retention | |||
Milnacipran | 1. Concomitant use of monoaminooxidase inhibitors | 1. Suicidality | Jan. 2009 |
2. Uncontrolled narrow-angle glaucoma | 2. Hepatotoxicity | ||
3. Substantial alcohol use or evidence of chronic liver damage | 3. Serotonin syndrome | ||
 | 5. Abnormal bleeding | ||
6. Discontinuation syndrome | |||
7. Elevated blood pressure | |||
8. Urinary hesitation and retention | |||
9. Seizures | |||
Tricyclic agents | 1. Prior hypersensitization | 1. Suicidality | Amitriptyline Jan. 2010 |
2. Concomitant use of monoaminooxidase inhibitors | 2. Anxiety and insomnia | ||
3. Acute recovery phase following myocardial infarction | 3. Activation of mania/hypomania and schizophrenia | ||
 | 4. Cardiovascular disorders | ||
5. Hyperthyroid patients or those receiving thyroid medication | |||
6. Elective surgery | |||
7. Elevated or lowered blood sugar | |||
8. Impaired liver function | |||
Serotonin reuptake inhibitors | 1. Concomitant use of monoaminooxidase inhibitors, thioridazine and pimozide | 1. Suicidality | Fluoxetine April 2011 |
2. Abnormal bleeding | |||
3. Anxiety and insomnia | |||
4. Activation of mania/hypomania | Paroxetine July 2011 | ||
5. Hyponatremia | |||
6. Seizures |