Bimodal distribution of STAT1 into high and low groups. (A) The log10 transformation of STAT1 shows a bimodal distribution of STAT1 with two populations (high- and low-STAT1 groups) with a cut off at 1.5 log[relative fold-change] of STAT1 (Log[STAT1]) for both healthy donor (HD) and SLE patient visits. (B) The low-STAT1 groups displayed significant difference of STAT1 in SLE patient visits compared to HD. (C) On the other hand, the high-STAT1 groups showed no significant difference between SLE and HD. (D, E) In the low-STAT1 group, STAT1 levels display a direct correlation to the IFN score in SLE patient visits and HD. STAT, signal transducers and activators of transcription.