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Table 1 Studies on vascular reactivity in animal models of arthritis

From: Mechanisms of endothelial dysfunction in rheumatoid arthritis: lessons from animal studies

Authors (year) Animal strain Arthritis model Arthritogenetic agent( injection zone) Time after induction of arthritis Response to ACh Response to SNP Response to vasoconstrictors
Fang et al. [14] (1991) Male Wistar rat AIA M. butyricum (tail) Day 26 = PE = KCl =
Cinar et al. [15] (1998) Male rat (strain NR) AIA M. tuberculosis (pad) Day 26 = PE ↑ KCl =
Ulker et al. [16] (2000) Male Wistar rat AIA M. tuberculosis (pad) Day 29 ↓ in grade 2 and 3 = in grade 1 ↓ in grade 2 and 3 = in grade 1 PE ↑ in grade 2, PE ↓ in grade 3, KCl ↑ in grade 2, KCl = in grade 1 and 3
Can et al. [17] (2002) Male Wistar rat AIA M. tuberculosis (pad) Day 26 = NR
Haruna et al. [18] (2006) Male Lewis rat AIA M. butyricum (tail) Day 35 = NR
Haruna et al. [19] (2007) Male Lewis rat AIA M. butyricum (tail) Day 35 = NR
Nozaki et al. [20] (2007) Male Lewis rat AIA M. butyricum (tail) Day 24 = NR
Sakuta et al. [21] (2010) Male Lewis rat AIA M. butyricum (tail) Day 35 = NR
Prati et al. [22] (2011) Male Lewis rat AIA M. butyricum (tail) Day 35 = KCl =
Prati et al. [23] (2012) Male Lewis rat AIA M. butyricum (tail) Day 35 = NE, ANG-II, ET-1=
Reynolds et al. [24] (2012) Male DBA/1 mice CIA Chick collagen (NR) Day 24-27 = = Serotonin ↓, KCl ↓
He et al. [25] (2013) Male DBA/1 mice CIA Bovine collagen (tail) Day 56 = NR
  1. Vascular reactivity was studied in the model of isolated aortic rings. ↑, increased; ↓, decreased; =, unchanged; ACh, acetylcholine; AIA, adjuvant-induced arthritis; ANG-II, angiotensin II; CIA, collagen-induced arthritis; ET-1, endothelin-1; KCl, high potassium chloride; NE, norepinephrine; NR, not reported; PE, phenylephrine; SNP, sodium nitroprusside.