Table 1 Studies on vascular reactivity in animal models of arthritis
From: Mechanisms of endothelial dysfunction in rheumatoid arthritis: lessons from animal studies
Authors (year) | Animal strain | Arthritis model Arthritogenetic agent( injection zone) | Time after induction of arthritis | Response to ACh | Response to SNP | Response to vasoconstrictors |
|---|---|---|---|---|---|---|
Fang et al. [14] (1991) | Male Wistar rat | AIA M. butyricum (tail) | Day 26 | ↓ | = | PE = KCl = |
Cinar et al. [15] (1998) | Male rat (strain NR) | AIA M. tuberculosis (pad) | Day 26 | ↓ | = | PE ↑ KCl = |
Ulker et al. [16] (2000) | Male Wistar rat | AIA M. tuberculosis (pad) | Day 29 | ↓ in grade 2 and 3 = in grade 1 | ↓ in grade 2 and 3 = in grade 1 | PE ↑ in grade 2, PE ↓ in grade 3, KCl ↑ in grade 2, KCl = in grade 1 and 3 |
Can et al. [17] (2002) | Male Wistar rat | AIA M. tuberculosis (pad) | Day 26 | ↓ | = | NR |
Haruna et al. [18] (2006) | Male Lewis rat | AIA M. butyricum (tail) | Day 35 | ↓ | = | NR |
Haruna et al. [19] (2007) | Male Lewis rat | AIA M. butyricum (tail) | Day 35 | ↓ | = | NR |
Nozaki et al. [20] (2007) | Male Lewis rat | AIA M. butyricum (tail) | Day 24 | ↓ | = | NR |
Sakuta et al. [21] (2010) | Male Lewis rat | AIA M. butyricum (tail) | Day 35 | ↓ | = | NR |
Prati et al. [22] (2011) | Male Lewis rat | AIA M. butyricum (tail) | Day 35 | ↓ | = | KCl = |
Prati et al. [23] (2012) | Male Lewis rat | AIA M. butyricum (tail) | Day 35 | ↓ | = | NE, ANG-II, ET-1= |
Reynolds et al. [24] (2012) | Male DBA/1 mice | CIA Chick collagen (NR) | Day 24-27 | = | = | Serotonin ↓, KCl ↓ |
He et al. [25] (2013) | Male DBA/1 mice | CIA Bovine collagen (tail) | Day 56 | ↓ | = | NR |