Skip to main content


Figure 4 | Arthritis Research & Therapy

Figure 4

From: Increased physical activity severely induces osteoarthritic changes in knee joints with papain induced sulfate-glycosaminoglycan depleted cartilage

Figure 4

Histology of safranin-O-stained sagittal sections of medial and lateral tibia plateau cartilage after 6 weeks and 12 weeks of follow-up. Both in sedentary and in running animals, cartilage of papain-injected joints was severely sulfated-glycosaminoglycan depleted at 6 weeks and 12 weeks. But in running animals, the extracellular matrix showed clear signs of erosion in the medial compartment and even denudation of bone in the lateral compartment.

Back to article page