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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Increased physical activity severely induces osteoarthritic changes in knee joints with papain induced sulfate-glycosaminoglycan depleted cartilage

Figure 4

Histology of safranin-O-stained sagittal sections of medial and lateral tibia plateau cartilage after 6 weeks and 12 weeks of follow-up. Both in sedentary and in running animals, cartilage of papain-injected joints was severely sulfated-glycosaminoglycan depleted at 6 weeks and 12 weeks. But in running animals, the extracellular matrix showed clear signs of erosion in the medial compartment and even denudation of bone in the lateral compartment.

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