Survivin but not Fms-like tyrosine kinase 3 ligand is up-regulated before the onset of rheumatoid arthritis: a pilot study

Table 2 Sensitivity (%) and specificity (%) for presymptomatic individuals and rheumatoid arthritis patients. Odds ratio with 95% confidence interval, PPV and NPV calculated for presymptomatic individuals

	RA patients (%)	Pre RA (%)	Specificity (%)	OR^a	95% CI^a	P value^a	PPV (%)	NPV (%)
Survivin	63.9	36.2	88.3	3.43	1.62-7.23	0.0008	43.6	81.6
Flt3L	33.3	6.4	95.5	1.43	0.36-5.77	0.61374	30.0	77.1

CI, confidence interval; Flt3L, Fms-like tyrosine kinase 3 ligand; NPV, negative predictive value calculated for the presymptomatic individuals; OR, odds ratio; PPV, positive predictive value calculated for the presymptomatic individuals; RA, rheumatoid arthritis. ^aCalculated for presymptomatic individuals compared with controls.

ISSN: 1478-6362