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Table 4 Meta-analysis of association of four single-nucleotide polymorphisms with changes in Disease Activity Score in 28 joints in all available studies a

From: Lack of validation of genetic variants associated with anti–tumor necrosis factor therapy response in rheumatoid arthritis: a genome-wide association study replication and meta-analysis

   rs12081765   rs1532269   rs17301249   rs7305646  
Study MAF P-value β MAF P-value β MAF P-value β MAF P-value β
Plant et al. [8] Cohort 1 (n = 566) 0.43 7.52E-04 0.29 0.37 7.11E-04 0.3 0.20 3.37E-04 −0.38 0.47 9.16E-04 −0.28
Cohort 2 (n = 379) 0.46 0.062 0.19 0.35 0.079 0.19 0.19 0.045 −0.24 0.49 0.049 −0.21
Cohort 3 (n = 341) 0.47 0.712 0.04 0.34 0.701 0.04 0.19 0.261 −0.14 0.50 0.292 −0.11
Krintel et al. [9] Copenhagen cohort (n = 196) 0.47 0.940 0.008 0.36 0.360 0.116 0.18 0.570 0.89 0.48 0.740 0.042
Umicevic Mirkov et al. [10] Dutch stage 1 cohort (n = 882) 0.39 0.730 −0.024 0.43 0.920 0.051 0.18 0.360 −0.05 0.50 0.390 0.05
Present study Collection 1 (n = 438) 0.42 0.570 0.055 0.38 0.831 0.020 0.12 0.181 −0.190 0.47 0.244 −0.117
Collection 2 (n = 196) 0.46 0.995 0.001 0.42 0.830 0.022 0.13 0.458 0.120 0.49 0.661 −0.049
Meta-analysis N = 2,998   0.102 0.068   0.0033 0.107   0.063 −0.138   0.085 −0.095
  1. aMAF, Minor allele frequency.