Lack of validation of genetic variants associated with anti–tumor necrosis factor therapy response in rheumatoid arthritis: a genome-wide association study replication and meta-analysis

Table 4 Meta-analysis of association of four single-nucleotide polymorphisms with changes in Disease Activity Score in 28 joints in all available studies ^a

		rs12081765			rs1532269			rs17301249			rs7305646
Study		MAF	P-value	β	MAF	P-value	β	MAF	P-value	β	MAF	P-value	β
Plant et al. [8]	Cohort 1 (n = 566)	0.43	7.52E-04	0.29	0.37	7.11E-04	0.3	0.20	3.37E-04	−0.38	0.47	9.16E-04	−0.28
	Cohort 2 (n = 379)	0.46	0.062	0.19	0.35	0.079	0.19	0.19	0.045	−0.24	0.49	0.049	−0.21
	Cohort 3 (n = 341)	0.47	0.712	0.04	0.34	0.701	0.04	0.19	0.261	−0.14	0.50	0.292	−0.11
Krintel et al. [9]	Copenhagen cohort (n = 196)	0.47	0.940	0.008	0.36	0.360	0.116	0.18	0.570	0.89	0.48	0.740	0.042
Umicevic Mirkov et al. [10]	Dutch stage 1 cohort (n = 882)	0.39	0.730	−0.024	0.43	0.920	0.051	0.18	0.360	−0.05	0.50	0.390	0.05
Present study	Collection 1 (n = 438)	0.42	0.570	0.055	0.38	0.831	0.020	0.12	0.181	−0.190	0.47	0.244	−0.117
Present study	Collection 2 (n = 196)	0.46	0.995	0.001	0.42	0.830	0.022	0.13	0.458	0.120	0.49	0.661	−0.049
Meta-analysis	N = 2,998		0.102	0.068		0.0033	0.107		0.063	−0.138		0.085	−0.095

ISSN: 1478-6362