Figure 4

Enhanced uptake of [¹⁸F ]DPA-714 in paws (ankle) of RA rats versus control using microPET. (A) Representative images in coronal sections of the increased uptake of [¹⁸F]DPA-714 in the ankles of a Mtb-treated (RA) rat (A, i) compared to non-treated (control) rat (A, ii) at 20 days. (B) Kinetics of [¹⁸F]DPA-714 uptake for non-treated and Mtb-treated (RA) rats. (C) Mean of [¹⁸F]DPA-714 uptake at 55 minutes for treated (RA) (n = 11) versus non-treated (control) (n = 6) group. **P = 0.00008. Mtb, Mycobacterium tuberculosis H37 Ra; PET, positron emission tomography; RA, rheumatoid arthritis.