Figure 5

(R) -[¹¹C]PK11195, [¹¹C]DPA-713 and [¹⁸F]DPA-714 bone uptake. Absolute uptake (A) and arthritic knee-to-bone ratios (B) of [¹¹C]DPA-713 (dark grey bars) and [¹⁸F]DPA-714 (light grey bars) compared with that of (R)-[¹¹C]PK11195 (black bars) obtained from ex vivo tissue distribution studies. Results are presented as mean ± SD of five arthritic rats for (R)-[¹¹C]PK11195, seven arthritic rats for [¹¹C]DPA-713 and six arthritic rats for [¹⁸F]DPA-714. SD, standard deviation.